153356-74-2

Upstream product

• 4667-74-7 3,4-dimethoxyphthalimide 
• 1567-56-2 3,4-dimethoxyphthalic anhydride 
• 4463-33-6 1,2-dimethoxy-3-methylbenzene 
• 16273-16-8 2,3-dimethoxy-6-methylbenzaldehyde 
• 518-90-1 3,4-dimethoxy-phthalic acid 
• 2051-90-3 Dichlorodiphenylmethane 
• 153356-72-0 4,5-dihydroxyisoindoline-1,3-dione 

Downstream Products

• 153356-78-6 (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-1-carboxy-1-methyl-ethoxyimino]-acetylamino}-3-(6,8-dioxo-2,2-diphenyl-6,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-7-ylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 153356-76-4 N-carboethoxy diphenylmethylenedioxyphthalimide 

Relevant academic research and scientific papers

Cephem compounds

Cephalosporin antibiotics having a 3-position substituent of the formula: STR1 are described, wherein X is --CO--, --SO2 -- or --COCH2 --; Y is --CO--, --SO2 -- or --CH2 --; Q is a benzene, pyridine or naphthalene ring, R1 and R2 are ortho with respect to each other and are independently hydroxy or of the formula O--M wherein M is a moiety and the O--M bond is cleavable in vivo and ring Q may be further substituted by a variety of atoms and groups. Processes for their preparation and use are described.

Synthesis and biological activity of C-3' ortho dihydroxyphthalimido cephalosporins

A series of C-3' ortho dihydroxyphthalimido cephalosporins 3~7 has been prepared by reaction of C-3' aminomethyl cephalosporin 411) with the corresponding N carboethoxyphthalimides 23 ~ 25, 37, 38. These new caphalosporins exhibit excellent in vitro Gram-negative activities, including Pseudomonas aeruginosa, excellent β-lactamases stability and pharmacokinetics equivalent or better than ceftriaxone.