16273-16-8Relevant academic research and scientific papers
Synthesis of oxygenated orthomethylbenzaldehydes via aryne [2+2] cycloaddition and benzocyclobutenol ring opening
Maturi, Mark M.,Ohmori, Ken,Suzuki, Keisuke
, p. 870 - 873 (2019/01/21)
Herein, a two-step procedure for the preparation of oxygenated ortho-methylbenzaldehyde derivatives, starting from commercially available bromoarenes, is described. The synthesis features the simultaneous and highly regioselective installation of both the methyl and the formyl group onto the benzene core via benzyne [2+2] cycloadditions with acetaldehyde lithium enolate to give the corresponding benzocyclobutenols in high yields. Bond-selective ring opening of the benzocyclobutenols under basic conditions in methanol delivers the title compounds.
Synthesis and biological activity of C-3' ortho dihydroxyphthalimido cephalosporins
Baudart,Hennequin
, p. 1458 - 1470 (2007/10/02)
A series of C-3' ortho dihydroxyphthalimido cephalosporins 3~7 has been prepared by reaction of C-3' aminomethyl cephalosporin 411) with the corresponding N carboethoxyphthalimides 23 ~ 25, 37, 38. These new caphalosporins exhibit excellent in vitro Gram-negative activities, including Pseudomonas aeruginosa, excellent β-lactamases stability and pharmacokinetics equivalent or better than ceftriaxone.
Cesium fluoride-mediated claisen rearrangement of aryl propargyl ether. Exclusive formation of 2-methylarylfuran and its availability as a masked salicylaldehyde
Ishii,Ishikawa,Takeda,Ueki,Suzuki
, p. 1148 - 1153 (2007/10/02)
Claisen rearrangement of an aryl propargyl ether in the presence of CsF led to exclusive formation of 2-methylarylfuran in excellent yield. The result of a precise examination of the rearrangement is described. Satisfactory transformation of the 2-methyla
