153413-51-5

Basic information

• Product Name: tert-butyl [N-(p-toluenesulfonyl)indol-3-yl]acetate
• Synonyms: tert-butyl [N-(p-toluenesulfonyl)indol-3-yl]acetate
• CAS NO: 153413-51-5
• Molecular Weight: 385.484
• Mol File: 153413-51-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl [N-(p-toluenesulfonyl)indol-3-yl]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [N-(p-toluenesulfonyl)indol-3-yl]acetate(153413-51-5)
• EPA Substance Registry System: tert-butyl [N-(p-toluenesulfonyl)indol-3-yl]acetate(153413-51-5)

Safety Data

• Hazardous Substances Data: 153413-51-5(Hazardous Substances Data)

Upstream product

• 1912-33-0 Indole-3-acetic acid methyl ester 
• 87-51-4 indole-3-acetic acid 
• 507-19-7 t-butyl bromide 
• 128742-77-8 [N-(p-toluenesulfonyl)indol-3-yl]acetic acid 

Relevant articles and documents

Catalytic asymmetric hydrogenation of indoles using a rhodium complex with a chiral bisphosphine ligand PhTRAP

Highly enantioselective hydrogenation of N-protected indoles was successfully developed by use of the rhodium catalyst generated in situ from [Rh(nbd)2]SbF6 and the chiral bisphosphine PhTRAP, which can form a trans-chelate complex with a transition metal atom. The PhTRAP-rhodium catalyst required a base (e.g., Cs2CO3) for the achievement of high enantioselectivity. Various 2-substituted N-acetylindoles were converted into the corresponding chiral indolines with up to 95% ee. The hydrogenations of 3-substituted N-tosylindoles yielded indolines possessing a stereogenic center at the 3-position with high enantiomeric excesses (up to 98% ee).