153428-01-4

Upstream product

• 15082-42-5 lithium benzyloxide 
• 153428-00-3 (R)-3-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-nonanoic acid tert-butyl ester 
• 111-64-8 n-octanoic acid chloride 
• 153427-99-7 (4S)-2,3,4,5-tetrahydro-4-(1-methylethyl)-N-octanoyloxazol-2-one 

Downstream Products

• 153428-07-0 (S)-2-[(R)-2-(Benzyloxycarbamoyl-methyl)-octanoyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 153428-05-8 (S)-2-[(R)-2-(2,2,2-Trichloro-ethoxycarbonylmethyl)-octanoyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 163388-97-4 (S)-2-[(R)-2-(Benzyloxycarbamoyl-methyl)-octanoyl]-3-methylcarbamoyl-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 153428-08-1 (S)-2-[(R)-2-(Benzyloxycarbamoyl-methyl)-octanoyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 
• 153428-06-9 (S)-2-((R)-2-Carboxymethyl-octanoyl)-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 153428-03-6 2,2,2-trichloroethyl 3-(R)-benzyloxycarbonylnonanoate 
• 153428-02-5 (R)-2-Hexyl-succinic acid 1-benzyl ester 

Relevant academic research and scientific papers

COLLAGENASE INHIBITOR

Compounds having inhibitory activity against inhibitory activity against type IV collagenase and are useful as angiogenesis, cancer infiltration or cancer metastasis inhibitors. The compounds have the formula: STR1 in which R 1 represents a group of formula:--OR. sup.3 (wherein R 3 represents a hydrogen atom or an alkyl group), --NR 4 R 5 (wherein R 4 and R 5 each represents a hydrogen atom, an alkyl or alkoxy group),--NHCH(R 6 COR 7 (wherein R 6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R 7 represents an alkyl group),--NHCH(R 6)COOR. sup.8 (wherein R 8 represents an alkyl group) or--NHCH(R 6)CONR 9 R 10 (wherein R 9 and R 10 each represents a hydrogen atom or an alkyl group, or NR 9 R 10 together represent a heterocyclic ring group); andR 2 represents a hydrogen atom, an alkyl or aralkyl group.

Synthesis and structure-activity relationships of gelatinase inhibitors derived from matlystatins

To investigate a series of new inhibitors of gelatinases based on matlystatin B (1b), extensive structure-activity relationship studies were performed. The new derivatives were evaluated in vitro for the ability to inhibit gelatinases. The inhibitory acti