153433-82-0Relevant articles and documents
Method for preparing optically active alpha-hydroxy-beta-amino acid compounds
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Paragraph 0046-0051, (2019/10/01)
The invention discloses a method for preparing optically active N-acyl-beta-hydroxy-amino ester compounds of formula II from alpha-acyloxy-beta-enamine ester compounds through a one-pot process. The method uses novel six-membered cyclic pyridinecarboxamid
Chemo- and biocatalytic strategies to obtain phenylisoserine, a lateral chain of Taxol by asymmetric reduction
Rimoldi, Isabella,Pellizzoni, Michela,Facchetti, Giorgio,Molinari, Francesco,Zerla, Daniele,Gandolfi, Raffaella
experimental part, p. 2110 - 2116 (2012/03/27)
Enriched ethyl 3-benzamido-2-hydroxy-3-phenylpropanoate (protected phenylisoserine), the chiral side chain of Taxol, was obtained via asymmetric reduction with transition metal-diphoshine complexes or with whole cells of non-conventional yeasts. Asymmetri
Synthesis of Four Chiral Pharmaceutical Intermediates by Biocatalysis
Patel, Ramesh N.,Banerjee, Amit,Szarka, Laszlo J.
, p. 1247 - 1264 (2007/10/03)
Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of four pharmaceutical drug candidates.These include: (i) the microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic ethyl ester to (3S,5R)-dihydroxy-6-(benzyloxy) he
Microbial Synthesis of (2R,3S)-(-)-N-benzoyl-3-phenyl isoserine ethyl ester-a taxol side-chain synthon
Patel, Ramesh N.,Banerjee, Amit,Howell, Jeffrey M.,McNamee, Clyde G.,Brozozowski, David,et al.
, p. 2069 - 2084 (2007/10/02)
The chiral intermediate (2R,3S)-(-)-N-benzoyl-3-phenyl isoserine ethyl ester 2a, a potential taxol 5 side-chain synthon, was prepared by microbial and enzymatic processes.Taxol 5, is an anticancer compound recently approved by FDA for the treatment of ova