153474-38-5Relevant articles and documents
New ruthenium catalysts containing chiral Schiff bases for the asymmetric hydrogenation of acetophenone
Karame, Iyad,Jahjah, Mohamed,Messaoudi, Abdelhalim,Tommasino, M. Lorraine,Lemaire, Marc
, p. 1569 - 1581 (2004)
A series of new chiral N4-Schiff bases, containing amine or sulfonamide functionalities has been synthesized. Coupled with ruthenium catalysts, these Schiff bases induce interesting results in the hydrogenation of acetophenone: complete conversion and 76% ee were obtained with the catalytic system Ru(PPh3)3Cl2/(1R,2R)-N,N′-bis-(2- p-tosylaminobenzylidene)-1,2-diphenylethylenediamine. A very important phosphine co-ligand effect was observed on both activity and enantioselectivity of the catalysts. However, without the co-ligand, we obtained an enantioselectivity for the (R)-enantiomer, whereas with nonchiral co-ligand an enantioselectivity for the (S)-enantiomer was observed.
Anxiolytic activity of analogues of 4-benzylamino-2-methyl-7H- pyrrolo[2,3-d]pyrimidines
Meade, Eric A.,Sznaidman, Marcos,Pollard, Gerald T.,Beauchamp, Lilia M.,Howard, James L.
, p. 363 - 374 (2007/10/03)
An extensive series of analogues of the lead anxiolytic 4-benzylamino- 2-methylpyrrolo[2,3-d]pyrimidine 1 was synthesized and evaluated in the Geller-Seifter conflict test for anxiolytic activity to discover a less toxic derivative. Analysis of the SAR revealed that the most potent compounds were those with meta substituents on the benzylamino ring. In this group the most promising derivatives were 4-[bis(3,5-dimethylamino)]benzylamino-2-methyl- 7H-pyrrolo[2,3-d]pyrimidine 12 and 4-(3,5-dimethylbenzylamino)-2-methyl-7H- pyrrolo[2,3-d]pyrimidine 24. Potential metabolites of 12 were synthesized and checked for their anxiolytic activity. Less toxic analogues of the second lead 24 were prepared by extending the alkyl groups attached to the benzene ring moiety. The addition of a fluoro substituent to the benzene moiety in the extended alkyl chain analogue 4-(3,5-diethyl-2-fluorobenzylamino)2- methyl-7H-pyrrolo[2,3-d]pyrimidine 34 resulted in a compound with a longer duration of activity relative to its analogue 4-(3,5-diethylbenzylamino)-2- methyl-7H-pyrrolo[2,3-d]pyrimidine 26.
