1535-76-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-2-(trifluoromethyl)phenol is used as a raw material for the synthesis of pharmaceuticals, contributing to the development of new drugs due to its unique chemical structure and properties.
Used in Agrochemical Industry:
4-AMINO-2-(TRIFLUOROMETHYL)PHENOL is also utilized as a starting material in the production of agrochemicals, playing a role in the creation of pesticides and other agricultural chemicals to protect crops.
Used in Dye and Pigment Production:
4-Amino-2-(trifluoromethyl)phenol is used as a component in the manufacturing of dyes and pigments, providing coloration and stability to various products.
Used in Polymer Industry:
It serves as a building block in the synthesis of polymers, which are essential in the production of plastics and other materials with diverse applications.
Used in Personal Care and Cosmetics:
This chemical is used in the formulation of personal care products and cosmetics, enhancing their performance and providing desired characteristics.
Used in UV Absorbers and Antioxidants:
4-Amino-2-(trifluoromethyl)phenol is employed as an intermediate in the production of UV absorbers and antioxidants, which are crucial for protecting materials from degradation caused by ultraviolet radiation.
Used as a Reagent in Organic Chemistry:
In the field of organic chemistry, 4-AMINO-2-(TRIFLUOROMETHYL)PHENOL is used as a reagent, facilitating various chemical reactions and contributing to the synthesis of complex organic molecules.
It is important to handle 4-amino-2-(trifluoromethyl)phenol with care due to its potential hazards if ingested, inhaled, or in contact with the skin. Proper safety protocols should be followed during its storage and use.

Upstream product

• 1548-61-4 4-nitro-2-(trifluoromethyl)phenol 
• 654-76-2 1-methoxy-4-nitro-2-(trifluoromethyl)benzene 
• 121-01-7 4-nitro-2-trifluoromethyl-aniline 
• 39062-69-6 4-benzyloxy-3-trifluoromethyl-nitrobenzene 

Downstream Products

• 1536-65-8 2-Chlor-3-<3-trifluormethyl-4-hydroxy-phenyl-propionsaeure 
• 1391979-79-5 N-(5-(4-chloro-2-(trifluoromethyl)phenoxy)-4-(3-cyanophenyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 1391980-14-5 3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile 
• 53903-51-8 2-trifluoromethyl-4-chlorophenol 
• 1197356-88-9 (4-hydroxy-3-trifluoromethylphenyl)-(all-trans)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid amide 
• 1197356-59-4 (4-hydroxy-3-trifluoromethylphenyl)-(all-trans)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid amide 
• 1197356-76-5 (4-amino-2-trifluoromethylphenyl)-(all-trans)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate 
• 1197356-48-1 4-amino-2-(trifluoromethyl)phenyl retinate 

Relevant academic research and scientific papers

Photochemistry of flutamide in various media: Investigation of the reaction mechanism as revealed by external magnetic field effects on product yields

Photochemistry of an anticancer drug flutamide, 2-methyl-N-[4-nitro-3- (trifluoromethyl) phenyl] propanamide has been investigated in various media in the absence and presence of 0.1 T magnetic field. On photoexcitation flutamide gives rise to a phenol de

Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists

A novel series of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as RORγt inverse agonists was discovered. Binding mode analysis of a RORγt partial agonist (2c) revealed by co-crystal structure in RORγt LBD suggests that the inverse agonists do not directly interfere with the interaction between H12 and the RORγt LBD. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as 3m with a pIC50 of 8.0. Selected compounds in the series showed reasonable activity in Th17 cell differentiation assay as well as low intrinsic clearance in mouse liver microsomes.

COMPOUNDS USEFUL AS RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS

Disclosed are retinoid-related orphan receptor gamma (RORγ) modulators of Formula (I) and their use in the treatment of diseases mediated by RORγ, wherein the radicals have the meanings as defined in the invention.

PYRROLIDINE DERIVATIVES AS ERK INHIBITORS

Disclosed are the ERK inhibitors of Formula (1.0): and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (1.0).