1535-91-7

Usage

Uses

1,2-Epoxy-3-(2,2,2-trifluoroethoxy)-propane is used as a chemical intermediate for various applications in the chemical industry. Its epoxy and trifluoroethoxy groups provide unique reactivity and stability, making it suitable for use in the synthesis of other compounds and materials.
Used in Chemical Industry:
1,2-Epoxy-3-(2,2,2-trifluoroethoxy)-propane is used as a building block for the synthesis of complex molecules and materials. Its unique structural composition allows for the creation of new compounds with potential applications in various fields.
Used in Pharmaceutical Industry:
1,2-Epoxy-3-(2,2,2-trifluoroethoxy)-propane is used as a key component in the development of new drugs. Its reactivity and stability can be harnessed to create novel drug candidates with improved properties, such as increased efficacy or reduced side effects.
Used in Material Science:
1,2-Epoxy-3-(2,2,2-trifluoroethoxy)-propane is used as a component in the development of new materials with specific properties. Its unique structure can contribute to the creation of materials with enhanced performance, such as improved strength, durability, or resistance to environmental factors.

InChI:InChI=1/C5H7F3O2/c6-5(7,8)3-9-1-4-2-10-4/h4H,1-3H2

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 106-89-8 epichlorohydrin 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 6226-25-1 2,2,2-trifluoroethyl trifluoromethanesulphonate 
• 556-52-5 oxiranyl-methanol 
• 764-23-8 3-(2,2,2-trifluoroethoxy)-1-chloropropan-2-ol 

Relevant academic research and scientific papers

Fluorinated glycidyl azide polymers as potential energetic binders

To improve the mechanical properties of glycidyl azide polymer (GAP)-based polyurethane network binders, a novel fluorinated glycidyl azide polymer, (2,2,2-trifluoro-ethoxymethyl epoxy-r-glycidyl azide) copolymer (poly(TFEE-r-GA)) was synthesized through an initial cationic copolymerization of epichlorohydrin and 2,2,2-trifluoro-ethoxymethyl epoxy, followed by azidation. The structure of poly(TFEE-r-GA) was characterized by FTIR, 1H NMR, 13C NMR and GPC. DSC and TGA were used to investigate the thermal behavior of poly(TFEE-r-GA), the glass transition temperature and decomposition temperature of poly(TFEE-r-GA) were found to be -49.5 and 250 °C, respectively. The copolyurethane networks were further synthesized by cross-linking poly(TFEE-r-GA) using trimethylolpropane as a chain extender agent, using isophorone diisocyanate as a cross-linking agent. In comparison with GAP, the poly(TFEE-r-GA) based copolyurethane networks exhibited relatively better mechanical properties, which had a tensile strength of 5.52 MPa, and an elongation at break of 162.8%. All the results indicated that the fluorine-containing GAP might serve as a potential energetic binder for future propellant formulations.

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

FLUORINATED HYPERBRANCHED POLYGLYCEROL POLYMERS AND CORRESPONDING NANOPARTICLES AND ENCAPSULANTS

Described herein are fluorinated hyper-branched polyglycerol ("HPG") polymers and corresponding synthesis methods. Also described herein are fluorinated HPG nanoparticles, drug encapsulated fluorinated HPG nanoparticles, and corresponding dispersions. Relative to corresponding non-fluorinated HPG polymers, the fluorinated HPG have desirable 19F nuclear magnetic resonance ("MR") activities for use as 19F magnetic resonance imaging ("MRI") probes. Furthermore, because the fluorinated HPG nanoparticles include, by definition, fluorine, drug loading and encapsulation efficiency is also significantly increased for fluorine containing drugs, relative to corresponding non-fluorinated HPG nanoparticles.

[(Polyfluoroalkoxy)methyl]thiiranes and 2-anilinoethanethiols

By reaction of appropriate oxiranes with thiourea [(polyfluoroalkoxy) methyl]-substituted thiiranes were obtained that are key compounds for the synthesis of perfluoro-containing 1,2-aminopropanethiols.

An Electron Spin Resonance Study of 3-Oxypropenoyl Radicals derived from Glycidols

Glycidols with blocked OH groups (A; M = alkyl or trialkylsilyl) react with t-butoxyl radicals to show the e.s.r. spectra of the corresponding 3-oxypropenoyl radicals (D), and 24 examples of these acyl radicals are reported.The reaction is thought to proceed through the formation of the allyloxyl radicals (B), which, in part, are converted into the aldehyde (C) which is very reactive towards loss of hydrogen to give the acyl radical (D).Glycidyl pivalate (A; M = COCMe3) reacts cleanly in this way, but glycidyl acetate (E; R = Me) also undergoes intramolecular 1,5-transfer of the acyl group to show the spectrum of the enoxyl radical (F).Glycidyl propionate and butyrate do not undergo this acyl transfer, but show the spectra of the radicals and (R' = Me or Et).