15352-99-5

Upstream product

• 105-31-7 1-hexyn-3-ol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 57189-00-1 propargylic tert-butoxy ether 

Downstream Products

• 54123-75-0 3-hydroxy-2-hexanone 
• 105-31-7 (S)-(-)-1-hexyn-3-ol 
• 70095-35-1 (R)-hex-1-yn-3-yl acetate 
• 105-31-7 (3R)-hex-1-yn-3-ol 
• 1000786-12-8 (S)-(-)-3-acetoxy-1-hexyne 
• 1432061-32-9 (R)-N-(hex-1-yn-3-yl)-2-methoxybenzenamine 
• 1291103-72-4 N-(R)-(hex-1-yn-3-yl)-N-methylbenzenamine 

Relevant academic research and scientific papers

New and efficient synthesis of 1,3-dienylphosphonates by palladium-catalyzed substitution of propargylic esters to diethyl phosphite

An efficient route to the synthesis of 1,3-dienylphosphonates (1) has been developed for the first time by the substitution of propargylic esters (2) to the diethyl phosphite (3) nucleophile in the presence of Pd2 (dba) 3 · CHCl3 (2 mol %) and 2,2′- bis(diphenylphosphino)-1,1′-binaphthyl (4 mol%). Both the alkyl and aryl 1,3-dienylphosphonates can be prepared from this transformation. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.

MILD PROTECTION AND DEPROTECTION OF ALCOHOLS AS TER-BUTYL ETHERS IN THE FIELD OF PHEROMONE SYNTHESIS

α,ο-Halohydrins and ο-acetylenic alcohols are protected as t-butyl ethers by reaction with isobutene and an acid catalyst : Amberlyst H-15. t-Butyl ethers are, in turn, cleaved to acetates by Ac2O and 10 percent FeCl3 in Et2O solvent.Under these mild conditions conjugated dieneic systems are neither destroyed nor isomerized.

Regiospecific Synthesis of a Terminal, Oxyfunctionalized Methyl Ketone Enamines via Catalytic Aminomercuriation of Prop-2-ynyl Esters and Ethers

Catalytic aminomercuriation of 1-substituted prop-2-ynyl esters and ethers (5) provides a mild, simple, and regiospecific route to the terminal functionalized enamines (6) despite the fact that they are potentially isomerisable to their internal form; hyd

Synthesis of optically active alkynyl alcohols and α-hydroxy esters by microbial asymmetric hydrolysis of the corresponding acetates

Asymmetric hydrolysis of the acetates of racemic alkynyl alcohols and α-hydroxy esters by Bacillus subtilis var. Niger afforded optically active acetates and alcohols in 7-90% optical purities. The both enantiomers of optically pure mandelie acid were prepared by this microbial method.