153541-15-2

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 108-94-1 cyclohexanone 
• 75-77-4 chloro-trimethyl-silane 
• 30683-77-3 cis-2-hydroxycyclohexanecarbonitrile 
• 4513-77-3 2-cyanocyclohexanone 

Relevant academic research and scientific papers

Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles

A stereoselective bioreduction of 2-oxocycloalkanecarbonitriles was concurrently coupled to a whole cell-catalyzed nitrile hydrolysis in one-pot. The first step, mediated by ketoreductases, involved a dynamic reductive kinetic resolution, which led to 2-hydroxycycloalkanenitriles in very high enantio- and diastereomeric ratios. Then, the simultaneous exposure to nitrile hydratase and amidase from whole cells of Rhodococcus rhodochrous provided the corresponding 2-hydroxycycloalkanecarboxylic acids with excellent overall yield and optical purity for the all-enzymatic cascade.

Enantioselective lewis acid catalysts of the early transition metals

Optionally active Lewis acid catalysts of the early transition metals which are useful in the catalysis of asymmetric additions have been prepared. The catalyst complexes comprise an alkoxide of a group IV or group V metal and an optically active trialkanolamine or dialkanolamine ligand.