20047-41-0

Basic information

• Product Name: [R,(+)]-2-Bromopropanoic acid methyl ester
• Synonyms: [R,(+)]-2-Bromopropanoic acid methyl ester;[R,(+)]-2-Bromopropionic acid methyl ester
• CAS NO: 20047-41-0
• Molecular Formula: C₄H₇BrO₂
• Molecular Weight: 167
• Mol File: 20047-41-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 145.9±8.0 °C(Predicted)
• Appearance: /
• Density: 1.496±0.06 g/cm3(Predicted)
• CAS DataBase Reference: [R,(+)]-2-Bromopropanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [R,(+)]-2-Bromopropanoic acid methyl ester(20047-41-0)
• EPA Substance Registry System: [R,(+)]-2-Bromopropanoic acid methyl ester(20047-41-0)

Safety Data

• Hazardous Substances Data: 20047-41-0(Hazardous Substances Data)

Usage

General Description

[R,(+)]-2-Bromopropanoic acid methyl ester is a chemical compound with the molecular formula C4H7BrO2. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and chemicals. It is a colorless liquid with a pungent odor and is highly flammable. [R,(+)]-2-Bromopropanoic acid methyl ester is mainly used in organic synthesis as a building block for the preparation of a wide range of organic compounds. Additionally, it is also used as a reagent in chemical reactions and as a solvent in various laboratory applications. However, it is important to handle and store this chemical with caution due to its flammability and potential health hazards.

Upstream product

• 186581-53-3 diazomethane 
• 32644-15-8 (S)-2-bromopropanoic acid 
• 5445-17-0 Methyl 2-bromopropionate 
• 205517-34-6 (3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione 
• 17392-83-5 (R)-Methyl lactate 
• 67-56-1 methanol 
• 7148-74-5 (S)-2-bromopropionyl chloride 
• 590-92-1 3-Bromopropionic acid 

Downstream Products

• 54656-65-4 (S)-2-methoxypropionic acid methyl ester 
• 54656-63-2 methyl (2R)-2-methoxypropanoate 
• 10009-70-8 R-(+)-2-bromopropionic acid 
• 121486-79-1 (S)-(-)-methyl 2-nitrooxypropionate 
• 74254-54-9 (-)-(S)-methyl 3,3-bis(benzyloxycarbonyl)-2-methylvalerate 
• 115880-50-7 (R)-2-phenoxypropanoic acid methyl ester 
• 153545-97-2 (R)-(+)-2-(4-methylphenoxy)propanoate 
• 99210-92-1 (R)-2-(4-chlorophenoxy)propanoic acid methyl ester 
• 140146-14-1 (R)-methyl 2-(3-chlorophenoxy) propionate 
• 153546-07-7 methyl (R)-2-(3-nitrophenoxy)propionate 
• 140146-13-0 (R)-methyl 2-(2-chlorophenoxy) propionate 
• 153472-86-7 (R)-methyl 2-(4-phenoxyphenoxy)propanoate 

Relevant articles and documents

USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3K-DELTA RELATED DISORDERS

The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I: or pharmaceutically acceptable salts thereof.

Study of the lanthanide-catalyzed, aqueous, asymmetric Mukaiyama aldol reaction

The development of efficient methods for the asymmetric Mukaiyama aldol reaction in aqueous solution has received great attention. We have developed a new series of chiral lanthanide-containing complexes that produce Mukaiyama aldol products with outstanding enantioselectivities. In this paper, we describe an optimized ligand synthesis, trends in stereoselectivity that result from changing lanthanide ions, and an exploration of substrate scope that includes aromatic and aliphatic aldehydes and silyl enol ethers derived from aromatic and aliphatic ketones.

A new class of ligands for aqueous, lanthanide-catalyzed, enantioselective Mukaiyama aldol reactions

The development of aqueous methods for generating enantiopure β-hydroxy carbonyl compounds is an important goal because these subunits compose many bioactive compounds and the ability to synthesize these groups in water has environmental and cost benefits. In this communication, we report a new class of ligands for aqueous, lanthanide-catalyzed, asymmetric Mukaiyama aldol reactions for the synthesis of chiral β-hydroxy ketones. Furthermore, we have used luminescence-decay measurements to unveil mechanistic information regarding the catalytic reaction via changes in water-coordination number. The precatalysts presented here yielded β-hydroxy carbonyls from aliphatic and aryl substrates with outstanding syn:anti ratios and enantiometric excesses of up to 49:1 and 97%, respectively.