15358-23-3

Usage

Uses

Used in Pharmaceutical Industry:
(5α,7β)-4,5-epoxy-17-methyl-3,6-dimethoxy-7β-acetyl-6,14-ethenomorphinan is used as a potential candidate for the development of new medications due to its possible analgesic, sedative, and antitussive effects. Its unique structure and properties make it a promising compound for pain management and cough suppression therapies.
Further research is required to fully understand the biological activities and potential therapeutic applications of (5α,7β)-4,5-epoxy-17-methyl-3,6-dimethoxy-7β-acetyl-6,14-ethenomorphinan, as its current understanding is limited.

Upstream product

• 115-37-7 thebaine 
• 78-94-4 methyl vinyl ketone 

Downstream Products

• 136232-95-6 buprenorphine hydrochloride 
• 52485-79-7 Buprenorphine 
• 22152-80-3 [5α,7α]-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-α,17-dimethyl-6,14-ethenomorphinan-7-methanol 
• 15358-22-2 thevinone 

Relevant academic research and scientific papers

Processes for the synthesis of opiates alkaloids with reduced impurity formation

The invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for the formation of opiate alkaloids that minimizes the formation of impurities.

Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO

Antagonist radiotracers have shown only a low sensitivity for detecting competition from high-efficacy agonists at opioid receptors (ORs) in vivo. We report that [11C]PEO binds with high affinity to μ and κ-opioid receptors, is a full agonist, and concentrates in brain regions of rats with a high density of the μ-OR after intravenous injection. Blocking studies with μ and κ-OR selective compounds demonstrated that the binding of [11C]PEO is saturable and selective to the μ-OR in rat brain.

Synthesis of N-substituted 7β-diprenorphine derivatives

The separation of thevinone (2a) and β-thevinone (2b), as well as that of dihydrothevinone (3a) and β-dihydrothevinone (3b) was accomplished. By the application of various procedures numerous new N-substituted Diprenorphine analogues (8a-f) with 7R absolute configuration were synthesized. Detailed pharmacological investigation of the prepared compounds may contribute to a better understanding of the structure-activity relationship of morphine alkaloids.