153587-01-0

Basic information

• Product Name: NS 1619
• Synonyms: 1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE;NS 1619;NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN;1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one;1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b
• CAS NO: 153587-01-0
• Molecular Formula: C₁₅H₈F₆N₂O₂
• Molecular Weight: 362.23
• Product Categories: API
• Mol File: 153587-01-0.mol
• Article Data: 2

Chemical Properties

• Appearance: white/solid
• Density: 1.563g/cm³
• Refractive Index: 1.538
• Storage Temp.: Store at +4°C
• Solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/m
• PKA: 8.32±0.48(Predicted)
• CAS DataBase Reference: NS 1619(CAS DataBase Reference)
• NIST Chemistry Reference: NS 1619(153587-01-0)
• EPA Substance Registry System: NS 1619(153587-01-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 153587-01-0(Hazardous Substances Data)

Usage

Description

NS 1619, also known as a large conductance calcium-activated potassium channels (BKCa) activator, is a member of the benzimidazoles class. It is characterized by its ability to activate BKCa channels, which play a crucial role in various physiological processes. NS 1619 has been shown to induce preconditioning in the heart, making it a potential candidate for therapeutic applications.

Uses

Used in Pharmaceutical Industry:
NS 1619 is used as a BKCa channel activator for its ability to induce preconditioning in the heart. This property makes it a promising candidate for the development of treatments aimed at protecting the heart from ischemic events and improving overall cardiac function.
Used in Research Applications:
In addition to its potential therapeutic applications, NS 1619 is also used as a research tool to study the role of BKCa channels in various physiological processes. By activating these channels, researchers can gain insights into the mechanisms underlying their function and explore their potential as targets for drug development.

Biochem/physiol Actions

NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.

InChI:InChI=1/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)

Upstream product

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Relevant articles and documents

Benzimidazole derivatives, their preparation and pharmaceutical use

A compound having the formula STR1 wherein X is O, SR 4, R 5, R 6 and R 7 independently of each other are hydrogen, halogen, or CF 3 ;R'' is hydrogen or NO 2 ; andfurther a method of treating a disorder or disease of a living animal body, including a huma