Heterocycles p. 775 - 789 (1993)
Update date:2022-08-04
Topics:
Cheng, Chia-Chung
Liu, Den-Fu
Chou, Ting-Chao
A number of substituted 3-phenylquinazolin-4-ones, 12H-benzoxazolo<2,3-b>quinazolin-12-ones and 12H-benzothiazolo<2,3-b>quinazolin-12-ones were designed and synthesized on the basis of a "2-phenylnaphthalene-type" structural pattern hypothesis.The posulated pattern, which was uncovered among a substantial number of compounds of both natural and synthetic origins, was noted to be associated with compounds possessing a variety of biological properties which include the antineoplastic activity.Several compounds designed for the present study were found to exhibit potentcytotoxicity against the growth of human promyelocytic leukemia (HL-60)cells.
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Doi:10.1021/acs.orglett.5b01484
(2015)Doi:10.1246/bcsj.66.2668
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(2014)