DESIGN OF ANTINEOPLASTIC AGENTS ON THE BASIS OF THE "2-PHENYLNAPHTHALENE-TYPE" STRUCTURAL PATTERN.I. SYHTHESIS OF SUBSTITUTED 3-PHENYLQUINAZOLONES, BENZOXAZOLOQUINAZOLONES AND BENZOTHIAZOLOQUINAZOLONES

Article abstract of DOI:10.3987/COM-92-S(T)51

A number of substituted 3-phenylquinazolin-4-ones, 12H-benzoxazolo<2,3-b>quinazolin-12-ones and 12H-benzothiazolo<2,3-b>quinazolin-12-ones were designed and synthesized on the basis of a "2-phenylnaphthalene-type" structural pattern hypothesis.The posulated pattern, which was uncovered among a substantial number of compounds of both natural and synthetic origins, was noted to be associated with compounds possessing a variety of biological properties which include the antineoplastic activity.Several compounds designed for the present study were found to exhibit potentcytotoxicity against the growth of human promyelocytic leukemia (HL-60)cells.