153805-85-7

Usage

Chemical class

Pyrrolidine derivative

Structural features

Contains a vinyl group
Contains a nitro phenyl group
Contains a benzyloxy group

Pharmacological properties

Potential anti-inflammatory activity
Potential analgesic activity

Potential applications

Nitroaromatic drug candidate
Target for further research in medicinal chemistry and drug development
These properties highlight the unique structure and potential therapeutic applications of 1-[2-(5-BENZYLOXY-2-NITROPHENYL)VINYL]PYRROLIDINE, making it an interesting compound for further investigation in the field of medicinal chemistry.

Upstream product

• 100-44-7 benzyl chloride 
• 2581-34-2 3-methyl-4-nitrophenol 
• 123-75-1 pyrrolidine 
• 22424-58-4 5-benzyloxy-2-nitrotoluene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1953-54-4 indol-5-ol 
• 1215-59-4 5-benzyloxy-1H-indole 
• 178945-27-2 2,5-dihydro-3-[6-benzyloxy-1-(tert-butyloxycarbonyl)-1H-indol-3-yl]-4-(5-benzyloxy-1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione 
• 178945-29-4 2,5-dihydro-3-(5-benzyloxy-1H-indol-3-yl)-4-(6-benzyloxy-1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Convenient modification of the Leimgruber-Batcho indole synthesis: Reduction of 2-nitro-p-pyrrolidinostyrenes by the FeCl3-activated carbon-N2H4H2O system

A new catalytic system containing ferric chloride, activated carbon, and hydrazine has been proposed for the reductive cyclization of β-dialkylamino-2-nitrostyrenes to give the corresponding indoles (Leimgruber-Batcho synthesis). Various substituted indoles may be obtained in high yield under these conditions.

Practical synthesis of indolopyrrolocarbazoles

A practical method for the synthesis of an indolo[2,3-a]pyrrolo[3,4- c]carbazole ring system is described. The method involves two key processes: a coupling reaction between indole and substituted methylmaleimide portions using lithium hexamethyldisilazide (LiHMDS) as a base, and the oxidative cyclization of bisindolylmaleimide with palladium (II) chloride. We applied this method to the synthesis of arcyriaflavin B (5), C (6) and D (7).