1538593-70-2

Upstream product

• 1538593-67-7 3-(5-bromo-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one 
• 1538593-69-9 2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-3-(2-isopropoxy-5-vinylphenyl)quinazolin-4(3H)-one 
• 383869-57-6 4-bromo-2-nitro-1-(propan-2-yloxy)benzene 

Downstream Products

• 1538593-71-3 2-((4-(2-(4-chlorophenoxy)ethanoyl)piperazin-1-yl)methyl)-3-(2-isopropoxy-5-(piperazin-1-ylmethyl)phenyl)qiuinazolin-4(3H)-one 

Relevant academic research and scientific papers

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

Introducing a reactive carbonyl to a scaffold that does not otherwise have an electrophilic functionality to create a reversible covalent inhibitor is a potentially useful strategy for enhancing compound potency. However, aldehydes are metabolically unsta

QUINAZOLINONE-BASED ONCOGENIC-RAS-SELECTIVE LETHAL COMPOUNDS AND THEIR USE

The present invention provides, inter alia, compounds having the structure (1) compositions containing such compounds are also provided. Methods for using such compounds or compositions for treating or ameliorating the effects of a cancer having a cell that harbors an oncogenic RAS mutation, for modulating a lipoxygenase in a ferroptosis cell death pathway, and for depleting reduced glutathione (GSH) in a cell harboring an oncogenic RAS mutation are further provided.