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Usage

Uses

Used in Pharmaceutical Industry:
N-(3-(TRIFLUOROMETHYL)PHENYL)SUCCINIMIDE is used as a synthetic intermediate for the production of pharmaceutical compounds, facilitating the creation of new drugs and enhancing existing ones due to its unique chemical structure.
Used in Agricultural Chemicals:
In the agricultural sector, N-(3-(TRIFLUOROMETHYL)PHENYL)SUCCINIMIDE is used as an intermediate in the synthesis of pesticides and herbicides, contributing to the development of more effective and targeted crop protection agents.
Used in Anti-Inflammatory and Anti-Cancer Research:
N-(3-(TRIFLUOROMETHYL)PHENYL)SUCCINIMIDE is studied for its potential anti-inflammatory and anti-cancer properties, indicating its use as a research compound in the development of new therapeutic agents for these conditions.
It is crucial to handle N-(3-(TRIFLUOROMETHYL)PHENYL)SUCCINIMIDE with care and adhere to safety protocols during its use, given its chemical nature and potential applications.

InChI:InChI=1/C11H8F3NO2/c12-11(13,14)7-2-1-3-8(6-7)15-9(16)4-5-10(15)17/h1-3,6H,4-5H2

Upstream product

• 123-56-8 Succinimide 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 368-49-0 3-(trifluoromethyl)phenyllithium 
• 108-30-5 succinic acid anhydride 
• 98-16-8 3-trifluoromethylaniline 

Relevant academic research and scientific papers

Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis

The thiazolidinone 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone (CFTRinh-172) inhibits cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel conductance with submicromolar affinity and blocks cholera toxin-induced intestinal fluid secretion. Fifty-eight CFTRinh-172 analogs were synthesized to identify CFTR inhibitors with improved water solubility, exploring modifications in its two phenyl rings, thiazolidinone core, and core-phenyl connectors. Greatest CFTR inhibition potency was found for 3-CF3 and polar group-substituted-phenyl rings, and a thiazolidinone core. Two compounds with ～1 μM CFTR inhibition potency and solubility >180 μM (>10-fold more than CFTRinh-172) were identified: Tetrazolo-172, containing 4-tetrazolophenyl in place of 4-carboxyphenyl, and Oxo-172, containing thiazolidinedione in place of the thiazolidinone core. These water soluble thiazolidinone analogs had low cellular toxicity. The improved water solubility of Tetrazolo- and Oxo-172 make them potential lead candidates for therapy of secretory diarrheas and polycystic kidney disease.

Cupric acetate mediated N-arylation by arylboronic acids: A preliminary investigation into the scope of application

A range of NH substrates of varying nucleophilicity were reacted with a selection of electronically diverse aryl boronic acids in the presence of cupric acetate in order to evaluate the generality of a previously described N-arylation procedure. The results of that investigation are discussed.