153888-47-2

Basic information

• Product Name: Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
• Synonyms: Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
• CAS NO: 153888-47-2
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246.05802
• EINECS: -0
• Mol File: 153888-47-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 325.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.656±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -4.45±0.62(Predicted)
• CAS DataBase Reference: Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(153888-47-2)
• EPA Substance Registry System: Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(153888-47-2)

Safety Data

• Hazardous Substances Data: 153888-47-2(Hazardous Substances Data)

Usage

Uses

Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate is a starting material in the synthesis of Functionalized Tricyclic Pyrrolo-Pyridones

Upstream product

• 6018-41-3 methyl coumalate 
• 41668-13-7 5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylic acid 
• 74-88-4 methyl iodide 
• 6375-89-9 methyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 381247-99-0 methyl 5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylate 

Downstream Products

• 934189-20-5 methyl 5-(2,6-difluorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate 
• 939411-78-6 methyl 1-methyl-6-oxo-5-(pyridin-2-yl)-1,6-dihydropyridine-3-carboxylate 

Relevant articles and documents

Expeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C-N/C-C Bond Formations

The facile synthesis of both saturated and unsaturated tricyclic pyrrolo-pyridones starting from a single readily available, common monocyclic reagent has been developed. An intermolecular annulation via a tandem Buchwald-Hartwig/Heck reaction led to the synthesis of β-carbolinones. The analogous semisaturated tricyclic pyrrolo-pyridones were prepared in good to excellent yields by sequential Buchwald-Hartwig and Fischer indole reactions. The methods feature mild reaction conditions and good functional group tolerance.

PCSK9 INHIBITORS AND METHODS OF USE THEREOF

The invention relates to a novel inhibitor pharmacophore of PCSK9 and heteroaryl compounds that bind the PCSK9 protein.

PYRIDINYL BASED APOPTOSIS SIGNAL-REGULATION KINASE INHIBITORS

Apoptosis signal-regulating kinase 1 (ASK1) activation and signaling have been reported to play an important role in a broad range of diseases including neurodegenerative, cardiovascular, inflammatory, autoimmunity and metabolic disorders. Disclosed herein is the synthesis of pyridinyl derived therapeutic agents that function as inhibitors of ASK 1 as well as their pharmaceutical compositions and methods of use.