153907-31-4Relevant academic research and scientific papers
Synthesis, modeling and evaluation of 3′-(1-aryl-1H-tetrazol-5- ylamino)-substituted 3′-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors
Van Poecke, Sara,Negri, Ana,Janssens, Jolien,Solaroli, Nicola,Karlsson, Anna,Gago, Federico,Balzarini, Jan,Van Calenbergh, Serge
, p. 892 - 901 (2011/04/16)
Based on the presumed binding mode of an earlier identified inhibitor, we herein report new 3′-modified nucleosides as potent and selective inhibitors of mitochondrial thymidine kinase (TK2). A series of thirteen 3′-amino-, 3′-guanidino- and 3′-tetrazole-
