1539283-34-5Relevant articles and documents
Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases
Kato, Yuko,Fuchi, Nobuhiro,Nishimura, Yutaka,Watanabe, Ayano,Yagi, Mai,Nakadera, Yasuhito,Higashi, Eriko,Yamada, Masateru,Aoki, Takumi,Kigoshi, Hideo
, p. 565 - 570 (2014/01/23)
We identified 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted ureas as highly potent soluble epoxide hydrolase (sEH) inhibitors and orally active agents for treating chronic kidney diseases. Compound 19 exhibited excellent sEH inhibitory activity a