15403-10-8

Basic information

• Product Name: 3-methoxy-3-methyl-2-butanone oxime
• Synonyms: 3-methoxy-3-methyl-2-butanone oxime
• CAS NO: 15403-10-8
• Molecular Weight: 131.175
• Mol File: 15403-10-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methoxy-3-methyl-2-butanone oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-3-methyl-2-butanone oxime(15403-10-8)
• EPA Substance Registry System: 3-methoxy-3-methyl-2-butanone oxime(15403-10-8)

Safety Data

• Hazardous Substances Data: 15403-10-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 37557-67-8 2-chloro-2-methyl-3-nitrosobutane 
• 109-76-2 Trimethylenediamine 
• 2400-78-4 1,3-diamino-2-methylpropane 

Downstream Products

• 115-22-0 3-Hydroxy-3-methyl-2-butanone 
• 7803-49-8 hydroxylamine 

Relevant articles and documents

An Efficient Synthesis of Some 6-Substituted 4,8-Diaza-3,3,9,9-tetramethylundeca-2,10-dione Dioximes (Propylene Amine Oximes, PnAOs): Ligands for 99mTc Complexes Used in Structure Distribution Relationship (SDR) Studies

Technetium complexes of the ligand PnAO are of interest as commercial radiopharmaceuticals.In general, PnAOs are synthesized by alkylation of a propylenediamine derivative with 3-chloro-3-methyl-2-nitrosobutane (2).This alkylation reaction proved to be low yielding.With modestly bulky substituents at the 2-position of 1,3-diaminopropane, little or none of the required PnAO was obtained.As a result, an alternative approach of the synthesis of PnAO was developed.This method involved the alkylation of the propylenediamine with 3-bromo-3-methylbutan-2-one (18) followed by oximation of the resulting diamine-diketone (19).By this method, PnAOs were prepared in good yield, even with bulky C-2 substituents.Fourteen PnAO derivatives were prepareed by this method.We also describe the syntheses of several new propylenediamine dervatives.