15403-22-2

Upstream product

• 61266-36-2 methyl 4-(3-hydroxypropynyl)benzoate 
• 135998-88-8 methyl 4-(3-bromopropoxyl)benzoate 
• 151937-09-6 3-(4-methoxycarbonylphenyl)propanoic acid 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 73166-52-6 4-((E)-3-oxoprop-1-enyl)-benzoic acid methyl ester 
• 19473-96-2 4-(2-carboxyvinyl)benzoic acid methyl ester 
• 1571-08-0 methyl 4-formylbenzoate 
• 58810-87-0 4-(3-Hydroxy propyl)benzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 619-44-3 methyl 4-iodobenzoate 
• 113100-81-5 4-(3-oxo-propyl)-benzoic acid methyl ester 

Downstream Products

• 169318-07-4 methyl 4-(4-cyano-4-ethoxycarbonylbutyl)benzoate 
• 113100-86-0 4-(3-bromo-propyl)-benzoic acid methyl ester 
• 113100-81-5 4-(3-oxo-propyl)-benzoic acid methyl ester 
• 58810-87-0 4-(3-Hydroxy propyl)benzoic acid 
• 137281-39-1 C₁₅H₁₄N₄O₃ 
• 527681-32-9 methyl chromane-7-carboxylate 

Relevant academic research and scientific papers

Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).

Compound as protein degradation agent and preparation method and medical application thereof

The invention discloses a compound serving as a protein degrading agent and a preparation method and medical application thereof, and particularly discloses a compound represented by the formula (I) and a pharmaceutically acceptable salt thereof, and the

Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A2AReceptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents

Adenosine is an immunosuppressive factor in the tumor microenvironment mainly through activation of the A2A adenosine receptor (A2AR), which is a mechanism hijacked by tumors to escape immune surveillance. Small-molecule A2AR antagonists are being evaluat

Preparation method of pemetrexed acid

Belonging to the technical field of organic compound synthesis, the invention in particular relates to a preparation method of pemetrexed acid. The method is characterized by utilizing methyl p-formylbenzoate and malonic acid as the starting materials to synthesize the target product. Compared with the methods for synthesis of the compound reported in previous literatures, the method provided by the invention has the advantages of easily available raw materials, low price and no pollution, greatly reduces the production cost, and is suitable for large-scale industrial production. The method isa brand new synthetic route for the compound.

METHOD FOR PRODUCING ALCOHOL BY HYDROGENATION OF CARBOXYLIC ACID COMPOUND, AND RUTHENIUM COMPLEX FOR USE IN THE PRODUCTION METHOD

PROBLEM TO BE SOLVED: To provide a method of obtaining an alcohol by efficiently hydrogenating a variety of carboxylic acid compounds under mild conditions using a homogeneous catalyst. SOLUTION: The present invention provides a method of hydrogenating a carboxylic acid compound, in the presence of a ruthenium complex represented by RuXnYpZq, in an atmosphere of hydrogen [X is a group represented by the following formula; Y is a phosphine ligand having a substituted/unsubstituted alkyl group or a substituted/unsubstituted aryl group; Z is a ligand other than X and Y; n is 1 or 2; p is an integer of 1-4; q is an integer of 0-2] {R1 is H, a substituted/unsubstituted alkyl group or a substituted/unsubstituted aryl group; A1 and A2 independently represent O, NR4 (R4 is H, a substituted/unsubstituted alkyl group or a substituted/unsubstituted aryl group) or S; m is an integer of 1 or more; a solid line and a dashed line both represent a single bond or a double bond}]. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Fluorene derivative

The invention relates to novel fluorene derivatives, which are especially suitable for use in birefringent films with negative optical dispersion, to novel liquid crystal (LC) formulations and polymer films comprising them, and to the use of the fluorene

NOVEL PYRAZINE AMIDE COMPOUNDS

The present invention relates to compounds of formula 1 or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R4, R5, R6 and X? have the meanings as indicated in the specification, to their use as a medicament, to their use in the treatment of a disease selected from among respiratory diseases or complaints and allergic diseases of the airways, to pharmaceutical composition comprising at least one of said compound or a pharmaceutically acceptable salt thereof, as well as to medicament combinations containing one or more of said compounds or a pharmaceutically acceptable salt thereof.

NOVEL PYRAZINE AMIDE COMPOUNDS

The present invention relates to compounds of formula 1 or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6 and X- have one of the meanings as indicated in the specification, to their use as a medicament, to their use in the treatment of a disease selected from among respiratory diseases or complaints and allergic diseases of the airways, to pharmaceutical composition comprising at least one of said compound or a pharmaceutically acceptable salt thereof, as well as to medicament combinations containing one or more of said compounds or a pharmaceutically acceptable salt thereof.

METHOD FOR MANUFACTURING ALCOHOL BY HYDROGENATION OF CARBOXYLIC ACID COMPOUND AND ESTER COMPOUND

PROBLEM TO BE SOLVED: To provide a method for obtaining alcohol by hydrogenation of carboxylic acid compound efficiently by using a homogeneous system catalyst, especially a method for obtaining alcohol by hydrogenation of various carboxylic acid compound and ester compound by the homogeneous system catalyst efficiently even under alleviation condition. SOLUTION: A carboxylic acid compound and/or an ester compound is hydrogenated in a presence of a rhenium complex represented by ReXmYnZp, where X is a halogen atom, Y is same or different and each a ligand containing one or more phosphorus atom, Z is a ligand other than X and Y, m is an integer of 1 to 6, p is an integer of 0 to 2 and the sum of m, n and p is an integer of 2 to 6, and a specific alkali metal salt. COPYRIGHT: (C)2015,JPOandINPIT

Novel Pyrazolo[1,5-a]pyrimidines as Translocator Protein 18 kDa (TSPO) Ligands: Synthesis, in Vitro Biological Evaluation, [18F]-Labeling, and in Vivo Neuroinflammation PET Images

A series of novel pyrazolo[1,5-a]pyrimidines, closely related to N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide (2, DPA-714), were synthesized and biologically in vitro evaluated for their potential to bind