154047-45-7Relevant academic research and scientific papers
Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant
Berggren, Kristina,Johansson, Bjoern,Fex, Tomas,Kihlberg, Jan,Bjoerck, Lars,Luthman, Kristina
experimental part, p. 3463 - 3470 (2009/09/25)
Analogues of the irreversible protease inhibitors TPCK and TLCK have been synthesized and tested as inhibitors of the bacterial cysteine protease IdeS excreted by Streptococcus pyogenes. Eight compounds were identified as inhibitors of IdeS in an in vitro
A convenient synthetic route to enantiopure N-tosylazetidines from α-amino acids
Ghorai, Manas K.,Das, Kalpataru,Kumar, Amit
, p. 2471 - 2475 (2007/10/03)
A general and convenient synthetic route to various chiral 2-substituted- and 2,4-disubstituted-N-tosylazetidines (ee >99%) is described in good overall yields starting from chiral α-amino acids using very simple chemistry.
Ring-opening of N-tosyl aziridines by 2-lithiodithianes
Howson, William,Osborn, Helen M. I.,Sweeney, Joseph
, p. 2439 - 2446 (2007/10/02)
The reaction of lithiated dithianes 6-8 and 15 and 16 with enantiopure N-sulfonylated aziridines 1 and 2 leads via regiospecific nucleophilic ring-opening to enentiopure N-tosyl 2-(2'-dithianyl) secondary amines in good to excellent yields.These compounds
