154049-20-4Relevant academic research and scientific papers
Synthesis of Chiral Lithium Dialkoxyaminoborohydrides
Dubois, Laurent,Fiaud, Jean-Claude,Kagan, Henri B.
, p. 3803 - 3812 (1995)
A convenient synthesis of chiral dialkoxyaminoborohydrides from borane and some diethanolamines is described.Tis is a novel class of reducing agents which react with acetophenone to afford α-methyl benzyl alcohol in good yields but in low ee's.
LIGANDS AND COMPLEX COMPOUNDS CONTAINING THE SAME
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Page/Page column 7, (2010/02/14)
A ligand represented by the formula (1):R1R2N-Q1-X-Q2-NR3R4 wherein R1, R2, R3 and R4 are each the same or different and represent a group repres
Stereoselective Reduction of Prochiral Ketones, Using Aluminum Hydride Reagents Prepared from LiAlH4 and Chiral Diethanolamines
Vries, Erik F.J. de,Brussee, Johannes,Kruse, Chris G.,Gen, Arne van der
, p. 377 - 386 (2007/10/02)
The asymmetric reduction of prochiral ketones to chiral secondary alcohols by LiAlH4, modified with optically active diethanolamines, was studied.Asymmetric inductions of up to 94percent were obtained with these reagents.The stereoselectivity of the reaction was found to depend both upon the temperature at which the reduction was performed and upon the conditions under which the chiral aluminum hydride reagent had been prepared.By changing the substituents at the carbon atom α to nitrogen in the chiral auxiliary, either the (R)- and (S)-enantiomer of the secondary alcohol could be obtained in excess.
