154049-34-0Relevant articles and documents
Synthesis of 2S,5S- and 2R,5S-5-hydroxypipecolic acid via amide-methylenation of S-5-hydroxy-2-piperidone with dimethyltitanocene
Herdeis,Heller
, p. 2085 - 2094 (1993)
A route to 2S,5S-hydroxypipecolic acid is presented, starting with the enantiopure 5S-5-hydroxy-piperidone 7. The key step of this reaction sequence is the chemoselective methylation of the amide carbonyl group of 8 with dimethyltitanocene 9 to 10. The tr