Synthesis of 2S,5S- and 2R,5S-5-hydroxypipecolic acid via amide-methylenation of S-5-hydroxy-2-piperidone with dimethyltitanocene

DOI: 10.1016/S0957-4166(00)82257-0

Source and publish data:

Tetrahedron Asymmetry p. 2085 - 2094 (1993)

Update date:2022-07-30

Topics:

Authors:

Herdeis Herdeis

Heller Heller

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0957-4166(00)82257-0

A route to 2S,5S-hydroxypipecolic acid is presented, starting with the enantiopure 5S-5-hydroxy-piperidone 7. The key step of this reaction sequence is the chemoselective methylation of the amide carbonyl group of 8 with dimethyltitanocene 9 to 10. The tr

Full text of DOI:10.1016/S0957-4166(00)82257-0

Products guided by the article

Product name:methyl (2R,5R)-5-benzoyloxy-N-methoxycarbonyl-piperidine-2-carboxylate

Cas No:154049-34-0

R&D Labs maybe for 154049-34-0

ZhangJiaGang YaRui Chemical Co.,Ltd.

Contact:0512-58360968

Address:China JiangSu Province Zhang Jia Gang City YangShe Oriental Plaza Building 10 B307
HENAN NEW BLUE CHEMICAL CO.,LTD

website:http://www.newbluechem.com

Contact:86-371-55170693/55170694

Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China
Jiangxi Dongbang Pharmaceutical Co., Ltd.

Contact:+86-795-4433603, 4433388

Address:Fengxin Industrial Park, Fengxin County, Jiangxi Province, P.R.C
Li's chemicals

Contact:+86-15850770348

Address:51 OF XIANGFANGCUN ROAD, Nanjing 210002, China
LINAN HAIHUA CHEMICAL CO LTD

Contact:86-571-61063068

Address:LINAN

Relevant to this article

The Synthesis of a Conformationally Restrained, Combined Thromboxane Antagonist / Synthase Inhibitor Using an Intramolecular "Stille"- or "Grigg"-Palladium-Catalysed Cyclisation Strategy

Doi:10.1016/S0040-4039(00)61429-6
(1993)
Synthesis and antiviral evaluation of some C₃-symmetrical trialkoxy-substituted 1,3,5-triazines and their molecular geometry

Doi:10.1248/cpb.c15-00309
(2015)
A highly selective Ir-catalyzed borylation of 2-substituted indoles: a new access to 2,7- and 2,4,7-substituted indoles

Doi:10.1016/j.tetlet.2006.11.083
(2007)
Coordination (ag⁺) ion spray - Mass spectrometry of peroxidation products of cholesterol linoleate and cholesterol arachidonate: High-performance liquid chromatography - Mass spectrometry analysis of peroxide products from polyunsaturated lipid autoxidation

Doi:10.1021/ja001180f
(2000)
Parallel β-sheet conformation in macrocycles

Doi:10.1016/S0040-4020(01)80237-4
(1993)
Synthesis of β-keto-phosphotriesters using functionalized diazoketones

Doi:10.1080/00397919408012621
(1994)

Article Doi