154140-72-4

Upstream product

• 123-75-1 pyrrolidine 
• 104-53-0 3-phenyl-propionaldehyde 

Downstream Products

• 374627-54-0 3-benzyl-1,1,1-trifluoro-4-pyrrolidin-1-yl-but-3-en-2-one 
• 1147864-09-2 4-benzyl-3-(diphenylphosphoryl)-2-methyl-1H-pyrrol-1-ol 
• 1147863-95-3 diethyl 4-benzyl-1-hydroxy-2-methyl-1H-pyrrol-3-ylphosphonate 
• 374627-72-2 5-benzyl-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4-(trifluoromethyl)-1H-pyrimidin-2-one 
• 374627-66-4 5-benzyl-4-trifluoromethyl-2-trimethylsilanyloxy-pyrimidine 
• 374627-62-0 5-benzyl-4-methoxy-4-(trifluoromethyl)-3,4-dihydro-1H-pyrimidin-2-one 
• 374627-55-1 5-benzyl-2-methoxy-4-(trifluoromethyl)pyrimidine 
• 169614-76-0 6-benzyl-1,3-dimethyllumazine 

Relevant academic research and scientific papers

Synthesis of some cyclic and acyclic nucleoside analogues derived from 4-(trifluoromethyl)pyrimidines

Cyclic nucleoside analogues 10, 11, 13b-d and 17 and acyclic derivatives 19 and 20b-d were prepared from 4-trifluoromethylpyrimidones 4a and 5b-d.

Regioselective Synthesis of 6-Alkylated Lumazine Derivatives

The regiospecific synthesis of alkylated lumazines is achieved by hetero Diels-Alder addition between an oxadiazinone 2 and enamine.The reactions proceed stepwise by cycloaddition, decarboxylation and deamination to produce the 6-alkylated lumazines.

A facile new synthesis of aldehyde enamines in high yield and high purity

Aldehyde enamines were synthesized in excellent yield and purity by reacting an aldehyde with 2 equivalents of a secondary amine in cyclohexane in the presence of 1.5 equivalents of CaH2. Distilled yields ranged from 65%-92%.

178. Stereoselectivity of the Radical Reductive Alkylation of Enamines: Importance of the Allylic 1,3-Strain Model

Radical addition to enamines using Bu3SnH as reducing agent are reported (Schemes 2 and 4).The diastereoselectivity of these reactions was examined in different systems (Tables 1 and 2).Enamines derived from cyclic ketones such as cyclohexanone were alkyl