169614-76-0Relevant academic research and scientific papers
Regiospecific synthesis of 6-alkylated lumazine derivatives using silylenol ethers
Igarashi, Mamoru,Tada, Masaru
, p. 465 - 466 (1996)
The reaction of oxadiazinone with silylenol ethers gave regiospecifically 6-substituted lumazines by an hetero Diels-Alder addition followed by decarboxylation and silanol elimination.
Immunosuppressive effects of pteridine derivatives
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, (2008/06/13)
Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, being represented by the general formula (I). are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.
Immunosuppressive effects of pteridine derivatives
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Page 25, (2010/02/05)
Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts
Regioselective Synthesis of 6-Alkylated Lumazine Derivatives
Igarashi, Mamoru,Tada, Masaru
, p. 807 - 810 (2007/10/02)
The regiospecific synthesis of alkylated lumazines is achieved by hetero Diels-Alder addition between an oxadiazinone 2 and enamine.The reactions proceed stepwise by cycloaddition, decarboxylation and deamination to produce the 6-alkylated lumazines.
