169614-76-0

Basic information

• Product Name: 6-benzyl-1,3-dimethyllumazine
• Synonyms: 6-benzyl-1,3-dimethyllumazine
• CAS NO: 169614-76-0
• Molecular Weight: 282.302
• Mol File: 169614-76-0.mol

Chemical Properties

• CAS DataBase Reference: 6-benzyl-1,3-dimethyllumazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-1,3-dimethyllumazine(169614-76-0)
• EPA Substance Registry System: 6-benzyl-1,3-dimethyllumazine(169614-76-0)

Safety Data

• Hazardous Substances Data: 169614-76-0(Hazardous Substances Data)

Upstream product

• 51075-22-0 1-(trimethyl-silyloxy)-3-phenyl-1-propene 
• 15030-41-8 3,6,8-trioxo-5,7-dimethyl-5,6,7,8-tetrahydro-3H-pyrimido<5,4-c><1,2,5>oxadiazine 
• 104-53-0 3-phenyl-propionaldehyde 
• 5440-00-6 4,5-Diamino-1,3-dimethyluracil 
• 56485-04-2 benzylglyoxal 
• 6632-68-4 6-amino-1,3-dimethyl-5-nitroso-1H-pyrimidine-2,4-dione 
• 154140-72-4 (E)-1-(3-phenylprop-1-en-1-yl)pyrrolidine 

Relevant articles and documents

Regiospecific synthesis of 6-alkylated lumazine derivatives using silylenol ethers

The reaction of oxadiazinone with silylenol ethers gave regiospecifically 6-substituted lumazines by an hetero Diels-Alder addition followed by decarboxylation and silanol elimination.

Immunosuppressive effects of pteridine derivatives

Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, being represented by the general formula (I). are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.

Immunosuppressive effects of pteridine derivatives

Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts

Regioselective Synthesis of 6-Alkylated Lumazine Derivatives

The regiospecific synthesis of alkylated lumazines is achieved by hetero Diels-Alder addition between an oxadiazinone 2 and enamine.The reactions proceed stepwise by cycloaddition, decarboxylation and deamination to produce the 6-alkylated lumazines.