154148-69-3

Usage

Uses

Used in Pharmaceutical Research and Development:
5-AMINOMETHYL-PYRROLIDIN-2-ONE is utilized as a building block in the synthesis of various pharmaceuticals. Its presence in the molecular structure of drugs allows for the exploration of new therapeutic agents and the enhancement of existing ones, contributing to the advancement of medicinal chemistry.
Used in Organic Synthesis:
As a versatile compound in organic chemistry, 5-AMINOMETHYL-PYRROLIDIN-2-ONE is employed as a reagent in a multitude of chemical reactions. Its ability to participate in a range of reactions, including condensations, substitutions, and rearrangements, makes it an indispensable tool for the synthesis of complex organic molecules.
Used in Chemical Reactions:
5-AMINOMETHYL-PYRROLIDIN-2-ONE is used as a reagent in various chemical reactions due to its unique structure and functional groups. This allows for the creation of new compounds and the modification of existing ones, broadening the scope of chemical research and application.
Used in Research and Development of New Compounds:
5-AMINOMETHYL-PYRROLIDIN-2-ONE is employed in the research and development of new compounds, particularly in the field of organic chemistry. Its properties and reactivity make it a valuable component in the design and synthesis of novel molecules with potential applications in various industries.
Used in the Synthesis of Bioactive Molecules:
5-AMINOMETHYL-PYRROLIDIN-2-ONE is used as a key intermediate in the synthesis of bioactive molecules. Its incorporation into the molecular structure of these compounds can lead to the discovery of new pharmaceuticals with improved efficacy and selectivity, thereby enhancing the treatment options for various diseases and conditions.

InChI:InChI=1/C5H10N2O/c6-3-4-1-2-5(8)7-4/h4H,1-3,6H2,(H,7,8)

Upstream product

• 113466-82-3 5-(azidomethyl)-2-pyrrolidinone 
• 62400-75-3 pyroglutamol 
• 89717-54-4 (R,S)-4,5-diaminopentanoic acid dihydrochloride 
• 100556-54-5 C₁₁H₂₅NOSi₂ 
• 39716-58-0 pent-4-enoyl chloride 
• 6852-94-4 4-pentenamide 
• 591-80-0 pent-4-enoic acid 
• 5831-75-4 5-(iodomethyl)-2-pyrrolidinone 

Downstream Products

• 847492-34-6 5-{[(diphenylmethylene)amino]methyl}pyrrolidin-2-one 

Relevant academic research and scientific papers

IRAK4 INHIBITORS AND USES THEREOF

Compounds of Formula I as IRAK4 inhibitors are disclosed. The pharmaceutical compositions comprising compounds of formula I, methods of synthesis of these compounds, methods of treatment for diseases associated with IRAK-4 such as inflammatory diseases an

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

BICYCLIC PYRAZOLE DERIVATIVE

A compound represented by the following formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of either. These are compounds having high DPP-IV inhibitory activity and improved in safety, nontoxicity, etc. (I) [In the formula, R1 represents hydrogen, optionally substituted alkyl, etc.; the solid line and dotted line between A1 and A2 indicate a double bond (A1=A2), etc.; A1 represents a group represented by the formula C(R2), etc.; A2 represents a group represented by the formula C(R4), etc.; R2 represents hydrogen, optionally substituted alkyl, etc.; R4 represents hydrogen, optionally substituted alkyl, etc.; R6 represents hydrogen, optionally substituted aryl, etc.; and -Y represents, e.g.; a group represented by the formula (A): (A) (wherein ml is 0, 1, 2, or 3; and R7 is absent, or one or two R7's are present and each independently represents optionally substituted alkyl, etc.).]

Competitive intramolecular aminolysis: Relative rates of 5-and 6-membered lactam ring closure

Methyl 4,5-diaminopentanoate (4,5-Dape Me) undergoes competitive intramolecular aminolysis to 5-aminomethyl-2-pyrrolidinone (L5) and 5-amino-2-piperidinone (L6) in dilute alkaline aqueous solution at 25°C. Use of this single compound provides an ideal case for assessing the relative rates of 5- and 6-membered lactam ring closure. Assessments are also made using the intramolecular aminolysis of pairs of compounds: methyl 2,4-diaminobutanoate (2,4-Dab Me) and methyl 2,5-diaminopentanoate (2,5-Dape Me); methyl 4-aminobutanoate (4-Ab Me) and methyl 5-aminopentanoate (5-Ape Me).

Synthesis and Reactions of Iodo Lactams

The synthesis of a series of iodo lactams has been achieved by a new cyclization method that depends on generating N,O-bis(trimethylsilyl)imidate derivatives as intermediates.Treatment of an unsaturated amide with trimethylsilyl triflate in pentane and then iodine in tetrahydrofuran gives the iodo lactam.Some reactions of this new difunctional group with bases, nucleophiles, and Michael acceptors leading to functionalized or elaborated lactams are presented.In general, iodo lactams undergo direct SN2 reactions with reactive (but weakly basic) nucleophiles like azide and triphenylphosphine and elimination or decomposition in the presence of bases or basic nucleophiles.Sodium hydride may be used to generate an N-acylaziridine intermediate, which can be opened with azide to deliver an azido lactam with overall retention of stereochemistry.Silver-assisted solvolysis of iodo lactams gives the hydroxy lactams with retention of configuration, probably also because of participation by the lactam nitrogen.The sodium salt of 5-(iodomethyl)-2-pyrrolidinone (3), generated at -20 deg C, undergoes an annulation reaction with unsaturated esters (but not sulfones), leading to pyrrolizidine derivatives.

STEREOCONTROLLED SYNTHESIS OF DIAMINES FROM IODOLACTAMS

Displacement of iodide from iodolactams by azide occurs with retention of configuration if a catalytic amount of NaH is added, due to the intervention of an N-acyl-aziridine.Several diamine equivalents and a spermidine analogue are prepared in this way.