154185-27-0Relevant academic research and scientific papers
A new chemical access for 3'-acetyl-4'-hydroxychalcones using borontrifluoride-etherate via a regioselective Claisen-Schmidt condensation and its application in the synthesis of chalcone hybrids
Narender,Venkateswarlu,Nayak, B. Vishnu,Sarkar
, p. 5794 - 5798 (2011)
A new chemical access has been developed for the synthesis of 3'-acetyl-4'-hydroxychalcones from 1-(5-acetyl-2-hydroxy-phenyl)-ethanone and various substituted benzaldehydes via a regioselective Claisen-Schmidt condensation using borontrifluoride-etherate (BF3·OEt 2) at room temperature, in good to excellent yields within 12-24 h. Application of this methodology has also been demonstrated in the synthesis of chalcone hybrids.
