154226-77-4

Basic information

• Product Name: 2-bromo-1-(3,5-dimethylphenyl)ethan-1-one
• Synonyms: 2-bromo-1-(3,5-dimethylphenyl)ethan-1-one
• CAS NO: 154226-77-4
• Molecular Weight: 227.101
• Mol File: 154226-77-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-bromo-1-(3,5-dimethylphenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-(3,5-dimethylphenyl)ethan-1-one(154226-77-4)
• EPA Substance Registry System: 2-bromo-1-(3,5-dimethylphenyl)ethan-1-one(154226-77-4)

Safety Data

• Hazardous Substances Data: 154226-77-4(Hazardous Substances Data)

Upstream product

• 556-96-7 5-bromo-1,3-xylene 
• 5379-16-8 3,5-dimethylacetophenone 
• 77385-74-1 α-(3,5-dimethylphenyl)vinyl bromide 
• 22445-41-6 3,5-dimethylphenyl iodide 

Downstream Products

• 946619-77-8 C₂₀H₂₆N₂O₂ 
• 1455472-59-9 (1S)-2-bromo-1-(3,5-dimethylphenyl)ethan-1-ol 
• 1455472-60-2 (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)ethanol 
• 1455472-61-3 (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine 
• 1415829-52-5 N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide 
• 1415829-40-1 N-[3,5-(dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide 
• 1415830-23-7 8-chloro-3-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine 
• 1415830-22-6 2-[(3-chloropyrazin-2-yl)amino]-1-(3,5-dimethylphenyl)ethanone 
• 1415830-20-4 2-[(3-chloropyrazin-2-yl)amino]-1-(3,5-dimethylphenyl)ethanol 
• 1249418-20-9 2-amino-1-(3,5-dimethylphenyl)ethanol 
• 1415830-17-9 2-azido-1-(3,5-dimethylphenyl)ethanol 
• 1415830-15-7 2-azido-1-(3,5-dimethylphenyl)ethanone 
• 1415830-38-4 8-chloro-2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine 

Relevant articles and documents

2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS

The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.

Synthesis and biological evaluation of N-(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents

In this study, a series of novel N-(4-phenylthiazol-2-yl)cinnamamide derivatives (7a-8n) were synthesized and evaluated for their anti-proliferative activities in vitro by MTT assay and a possible antitumor mechanism was also explored. SAR analysis showed that steric effects played an important role on the anti-tumor activity. The most potent analogue 8f showed excellent inhibitions on the K562, Bel7402, A549 and Jurkat cells ranging from sub-micromolar to nanomolar concentration. Compound 8f inhibited Jurkat cells with an IC50 value of 0.035 μM with no apparent toxicity in different non-cancerous cells. Furthermore, it was suggested that the possible mechanism of 8f might be associated with inducing cancer cell apoptosis following flow cytometer analysis and Hoechst 33358 staining assays.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.