154226-77-4

Upstream product

• 22445-41-6 3,5-dimethylphenyl iodide 
• 556-96-7 5-bromo-1,3-xylene 
• 5379-16-8 3,5-dimethylacetophenone 
• 77385-74-1 α-(3,5-dimethylphenyl)vinyl bromide 

Downstream Products

• 1455472-59-9 (1S)-2-bromo-1-(3,5-dimethylphenyl)ethan-1-ol 
• 1455472-60-2 (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)ethanol 
• 1455472-61-3 (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine 
• 1415829-52-5 N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide 
• 1415829-40-1 N-[3,5-(dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide 
• 1415830-23-7 8-chloro-3-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine 
• 1415830-22-6 2-[(3-chloropyrazin-2-yl)amino]-1-(3,5-dimethylphenyl)ethanone 
• 1415830-20-4 2-[(3-chloropyrazin-2-yl)amino]-1-(3,5-dimethylphenyl)ethanol 
• 1249418-20-9 2-amino-1-(3,5-dimethylphenyl)ethanol 
• 1415830-17-9 2-azido-1-(3,5-dimethylphenyl)ethanol 
• 1415830-15-7 2-azido-1-(3,5-dimethylphenyl)ethanone 
• 1415830-38-4 8-chloro-2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine 
• 946619-77-8 C₂₀H₂₆N₂O₂ 

Relevant academic research and scientific papers

2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS

The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

Synthesis and biological evaluation of N-(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents

In this study, a series of novel N-(4-phenylthiazol-2-yl)cinnamamide derivatives (7a-8n) were synthesized and evaluated for their anti-proliferative activities in vitro by MTT assay and a possible antitumor mechanism was also explored. SAR analysis showed that steric effects played an important role on the anti-tumor activity. The most potent analogue 8f showed excellent inhibitions on the K562, Bel7402, A549 and Jurkat cells ranging from sub-micromolar to nanomolar concentration. Compound 8f inhibited Jurkat cells with an IC50 value of 0.035 μM with no apparent toxicity in different non-cancerous cells. Furthermore, it was suggested that the possible mechanism of 8f might be associated with inducing cancer cell apoptosis following flow cytometer analysis and Hoechst 33358 staining assays.

2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure-activity relationships of these inhibitors, which show potential as antibacterial agents.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

SUBSTITUTED 8 - AMINO - IMIDAZO [1, 2-A] PYRAZ1NES AS ANTIBACTERIAL AGENTS

The present invention relates to substituted imidazo[1,2-a]pyrazines of Formula (I) and their use as antibacterial agents.

Alkenyl bromides by brominative deoxygenation of ketones in one or two steps

The conversion of ketones into alkenyl bromides is accomplished in one or two steps by 2,2,2-tribromo-2,2-dihydro-1,3,2-benzodioxaphosphole or by the dibromomethyl methyl ether prepared therefrom. Investigations of the scope and limitations provide some hints for the preparative planning and improvement.