431075-50-2

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 532-55-8 Benzoyl isothiocyanate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1334511-26-0 1-benzoyl-3-(3'-chloro-4'-fluorophenyl)-4-methyl-1,3-dihydroimidazol-2-thione 
• 154371-25-2 1-(3-chloro-4-fluorophenyl)thiourea 

Relevant academic research and scientific papers

Synthesis and insecticidal activity of new substituted N-aryl-N′-benzoylthiourea compounds

Eight new substituted N -aryl- N ′-benzoylthioureas have been synthesised by a facile and mild method with high yield at room temperature. The structures of all compounds were confirmed by 1H NMR, mass and high resolution mass spectroscopy. The

Facile synthesis, antibacterial activity and molecular properties prediction of some new 1, 3-dihydroimidazol-2-thione derivatives

Present communication deals with the study of antibacterial activity and molecular properties prediction of some new 1, 3-dihydroimidazol-2-thione derivatives (1b-6b) obtained by cyclo-condensation reaction between 1-benzoyl-3-(substituted phenyl) thioureas (A) with triethylamine in the presence of bromine. The structures of these newly synthesized compounds were confirmed by their chemical, spectral and elemental analysis. All the compounds exhibited weak to moderate in-vitro antibacterial activity against representative Gram-positive and Gram-negative microorganisms. It was found that different substitution pattern on core bioactive scaffold 1, 3-dihydroimidazol-2-thione causes a dramatic variation in antibacterial profile. Target compounds were further subjected to molecular properties prediction and drug-likeness by Molinspiration and found in compliance with Lipinski 'Rule of Five' (Ro5) and presented a good drug-likeness score with no violations.

Synthesis and antibacterial activity of new N-acyl-N′-(3-chloro-4- fluorophenyl)thioureas

A new series of N-acyl-N′-(3-chloro-4-fluorophenyl)thioureas have been prepared in excellent yield by the reaction of acylthiocyanates and 3-chloro-4-fluoroaniline under solid-liquid phase transfer catalysis using PEG-400. All synthesised compounds were screened against Escherichia coli and Staphylococcus aureus in DMF for evaluating their antibacterial activity. 2d, 2e, 2f and 2g showed good activity at 50 μg/ml dilution.

One-pot three-step synthesis of 3-aryl-2-benzoylimino-4-thiazolidinones in the ionic liquid [bmim+][PF6-]

3-Aryl-2-acylimino-4-thiazolidinones are efficiently formed in 1-n-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] as solvent in a one-pot three-step procedure. The ionic solvent could be recovered and recycled four times with no diminution in yields.