154384-03-9Relevant academic research and scientific papers
A convenient synthesis of 5-deaza nonclassical antifolates: Reaction of cyanothioacetamide with sodium salts of 2-(hydroxymethylene)-1-cycloalkanones
Elgemeie, Galal E. H.,Hussain, Badria A. W.
, p. 199 - 204 (1994)
Condensation of cyanothioacetamide with sodium salts of 2-(hydroxymethylene)-1-cycloalkanones afforded the corresponding pyridine-2(1H)-thiones 4. Compounds 4 served as a key intermediate for the synthesis of condensed 2,4-diaminopyrido[2,3-d]pyridines 7. Compounds 7 were of interest as potential inhibitors of dihydrofolate reductase.
Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines
van Rensburg, Michelle,Leung, Euphemia,Haverkate, Natalie A.,Eurtivong, Chatchakorn,Pilkington, Lisa I.,Reynisson, Jóhannes,Barker, David
supporting information, p. 135 - 138 (2016/12/27)
3-Amino-2-arylcarboxamide-thieno[2,3-b]pyridines are a known class of antiproliferative compounds with activity against the phospholipase C enzyme. To further investigate the structure activity relationships of these derivatives a series of analogues were prepared modifying key functional groups. It was determined that modification of the 3-amino and 2-aryl carboxamide functionalities resulted in complete elimination of activity, whilst modification at C-5 allowed compounds of greater activity to be prepared.
