Tetrahedron p. 199 - 204 (1994)
Update date:2022-09-26
Topics:
Elgemeie, Galal E. H.
Hussain, Badria A. W.
Condensation of cyanothioacetamide with sodium salts of 2-(hydroxymethylene)-1-cycloalkanones afforded the corresponding pyridine-2(1H)-thiones 4. Compounds 4 served as a key intermediate for the synthesis of condensed 2,4-diaminopyrido[2,3-d]pyridines 7. Compounds 7 were of interest as potential inhibitors of dihydrofolate reductase.
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