15441-95-9

Upstream product

• 88-10-8 N,N-diethylcarbamyl chloride 
• 108-42-9 3-chloro-aniline 
• 109-89-7 diethylamine 
• 2909-38-8 m-chlorophenyl isocyanate 
• 21092-83-1 O-(m-Chlorphenyl-carbamoyl)-N-Methyl-N-acetyl-hydroxyl-amin 
• 20915-05-3 O-(m-Chlorphenyl-carbamoyl)-N_.N-diaethyl-hydroxylamin 

Downstream Products

• 1783-38-6 N-(m-Chlorphenyl)-N'.N'-diaethyl-formamidin 

Relevant academic research and scientific papers

Synthesis of 2,4-diaminoquinazoline derivatives

A series of 6- and 7-substituted derivatives of 2-(N,N-diethylamino)-4-(N,N-dimethylamino)quinazoline have been synthesized. The synthesis consists in converting N-phenyl-N',N'-diethylurea into chloroamidines which are treated with N,N-dimethylcyanamide t

INFRARED SPECTROSCOPIC AND CONFORMATIONAL STUDIES OF TRISUBSTITUTED UREAS CONTAINING CHLOROPHENYL GROUPS

The IR spectra, in the ν(N-H) region, of trisubstituted ureas R2UPhCl and RPhUPhCl containing a chlorophenyl group have been studied in order to examine the effects of the introduced chlorine atom.The out-trans-cis isomerism about the NH-CO rotational axis is discussed in reation to steric effect of the R2 group, Ph-Ph interaction and inter- and intra-molecular hydrogen bonding.In dilute solution, R2UPhCl exists in the trans or the out form, and RPhUPhCl in the cis form. o-Chlorophenyl derivatives show a monomeric ν(N-H) band at a wavenumber lower than that of the other derivatives and no associated ν(N-H) bands in concentrated or even in saturated solutions.Some of the derivatives are found to be in the same form in the solid state as in solution due to the retention of intra-molecular NH...Cl hydrogen bonding.

Process for the preparation of trisubstituted ureas

The present invention provides a process for preparing a trisubstituted urea of the general formula: in which R is a substituted or unsubstituted mono-, di- or polyvalent aromatic radical, R' is a substituted or unsubstituted monovalent aliphatic or aromatic radical and R is a substituted or unsubstituted monovalent aliphatic radical or R' and R together represent a substituted or unsubstituted divalent radical in which at least one of the two carbon atoms adjoining the nitrogen atom of the urea is aliphatic, and n is an integer, wherein an aromatic nitrocompound of the general formula:--R(NO2)n or an aromatic nitrosocompound of the general formula:--R(NO)n is allowed to react with a secondary ammonium N,N-disubstituted thiolcarbamate of the general formula: or with a mixture of a secondary amine of the general formula:--R'R NH and carbon monoxide and sulphur, carbon monoxide and hydrogen sulphide, or carbonyl sulphide, or with a mixture of a secondary ammonium sulphide or hydrosulphide of the general formula: or and carbon monoxide.