1544451-85-5Relevant academic research and scientific papers
Synthesis of Polysubstituted 2-Aminoimidazoles via Alkene-Diamination of Guanidine with Conjugated α-Bromoalkenones
Guchhait, Sankar K.,Hura, Neha,Shah, Archana P.
, p. 2745 - 2752 (2017/03/14)
A step-economical access to polysubstituted aminoimidazoles has been accomplished via alkene vicinal C-N bonds formation of 2-bromo-2-alkenones with guanidine avoiding its NH-protection/derivatization prerequisite for electronic modulation. The approach has excellent substrate scope, is amenable to diverse guanidine-containing substrates, and introduces distinctive substitutions/functionalities into aminoimidazole core. It is also applicable to preparation of fused-imidazoles. The reaction involves a tandem pathway of aza-Michael addition, SN2, and a unique redox-neutral process, as evident by spectroscopic study and control experiments.
Facile, efficient synthesis of polyfunctionalized 2-aminoimidazoles via vinyl azides and cyanamide
Liu, Shen,Shao, Jiaan,Guo, Xiao,Luo, Jing,Zhao, Menghao,Zhang, Guolin,Yu, Yongping
supporting information, p. 1418 - 1421 (2014/02/14)
A simple and direct synthesis of 2-aminoimidazoles from vinyl azides and cyanamide was developed. An attractive feature of this protocol is that the desired products are generated in a highly efficient and eco-friendly manner without the use of a catalyst. A plausible mechanism has been proposed.
