1544495-69-3

Basic information

• Product Name: (1S,2S,3S)-2-(4-(5-(difluoromethoxy)pyrimidin-2-yl)phenyl)-1-fluoro-N-hydroxy-3-phenylcyclopropanecarboxamide
• CAS NO: 1544495-69-3
• Molecular Weight: 415.372
• Mol File: 1544495-69-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,2S,3S)-2-(4-(5-(difluoromethoxy)pyrimidin-2-yl)phenyl)-1-fluoro-N-hydroxy-3-phenylcyclopropanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S,3S)-2-(4-(5-(difluoromethoxy)pyrimidin-2-yl)phenyl)-1-fluoro-N-hydroxy-3-phenylcyclopropanecarboxamide(1544495-69-3)
• EPA Substance Registry System: (1S,2S,3S)-2-(4-(5-(difluoromethoxy)pyrimidin-2-yl)phenyl)-1-fluoro-N-hydroxy-3-phenylcyclopropanecarboxamide(1544495-69-3)

Safety Data

• Hazardous Substances Data: 1544495-69-3(Hazardous Substances Data)

Upstream product

• 41570-67-6 1-benzyltetrahydro-1H-thiophen-1-ium bromide 
• 1192813-64-1 2-chloro-5-(difluoromethoxy)pyrimidine 
• 3650-78-0 methyl (E)-4-bromocinnamate 

Relevant articles and documents

Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors

Potent and selective class IIa HDAC tetrasubstituted cyclopropane hydroxamic acid inhibitors were identified with high oral bioavailability that exhibited good brain and muscle exposure. Compound 14 displayed suitable properties for assessment of the impact of class IIa HDAC catalytic site inhibition in preclinical disease models.