154459-76-4

Upstream product

• 288162-71-0 (R)-2-Benzyloxymethyl-[1,3]dioxolane-4-carboxylic acid methyl ester 
• 154371-93-4 (1S,2S)-1,2-Bis-((R)-2-benzyloxymethyl-[1,3]dioxolan-4-yl)-ethane-1,2-diol 

Downstream Products

• 307002-00-2 (2R)-2-benzyloxymethyl-4-acetoxy-1,3-dioxolane 
• 655245-86-6 2-Amino-7-((2R,4R)-2-benzyloxymethyl-[1,3]dioxolan-4-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 655245-84-4 7-(2-benzyloxymethyl-[1,3]dioxolan-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine 
• 501013-40-7 7-(2-benzyloxymethyl-[1,3]dioxolan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine 
• 501013-41-8 7-(2-benzyloxymethyl-[1,3]dioxolan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine 
• 501013-38-3 7-(2-benzyloxymethyl-[1,3]dioxolan-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication

A series of optically pure 1,3-dioxolane nucleoside mimics was synthesized by a synthetic route that allowed incorporation of a 5R-methyl substituent from commercially available starting materials. The pyrrolo[2,3-d]pyrimidine heterocycle was chosen as a

Divergent Asymmetric Syntheses of Dioxolane Nucleoside Analogues

Oxidative degradation of benzyloxymethylacetals derived from D-mannitol or L-ascorbic acid provides dioxolane intermediate 6 and 7 useful in the synthesis of all the stereoisomers of dioxolane nucleoside analogues.