307002-00-2Relevant academic research and scientific papers
Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication
Bera, Sanjib,Malik, Leila,Bhat, Balkrishen,Carroll, Steven S.,MacCoss, Malcolm,Olsen, David B.,Tomassini, Joanne E.,Eldrup, Anne B.
, p. 4455 - 4458 (2007/10/03)
A series of optically pure 1,3-dioxolane nucleoside mimics was synthesized by a synthetic route that allowed incorporation of a 5R-methyl substituent from commercially available starting materials. The pyrrolo[2,3-d]pyrimidine heterocycle was chosen as a
Structure-activity relationships among a new class of antiviral heterosubstituted 2',3'-dideoxynucleoside analogues
Mansour,Jin,Wang,Dixit,Evans,Tse,Belleau,Gillard,Hooker,Ashman,Cammack,Salomon,Belmonte,Wainberg
, p. 627 - 635 (2007/10/02)
3'-Oxa-4'-thiocytidine nucleoside analogues 14-17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found to possess potent activities against HIV-1 in a panel of cell lines. Compound 16 is moderately active against HBV in 2.2.15 cells.
Oxidative Degradation of L-Ascorbic Acid Acetals to 2',3'-Dideoxy-3'-Oxaribofuranosides. Synthesis of Enantiomerically Pure 2',3'-Dideoxy-3'-Oxacytidine Stereoisomers as Potential Antiviral Agents
Belleau, Bernard R.,Evans, Colleen A.,Tse, H. L. Allan,Jin, Haolun,Dixit, Dilip M.,Mansour, Tarek S.
, p. 6949 - 6952 (2007/10/02)
Enantiomerically pure 2',3'-dideoxy-3'-oxacytidine nucleoside analogues were synthesized from L-ascorbic acid in eight steps and good overall yield.
