1544673-61-1

Basic information

• Product Name: 2-[2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione
• Synonyms: 2-[2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione
• CAS NO: 1544673-61-1
• Molecular Weight: 377.248
• Mol File: 1544673-61-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione(1544673-61-1)
• EPA Substance Registry System: 2-[2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione(1544673-61-1)

Safety Data

• Hazardous Substances Data: 1544673-61-1(Hazardous Substances Data)

Upstream product

• 1544673-46-2 [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol 
• 1074-82-4 potassium phtalimide 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 1352132-34-3 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 1106869-99-1 (3-formyl-4-methylphenyl)boronic acid 

Downstream Products

• 1544673-80-4 [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine 

Relevant articles and documents

Synthesis of boron-containing primary amines

In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate esters in good to excellent yields. These compounds were further utilized to build peptoid analogs via an Ugi four-component reaction (Ugi-4CR) under microwave irradiation. The prepared Ugi-4CR boronate esters were then successfully converted to the corresponding boronic acids. Finally, the peptoid structures were successfully modified by cross-coupling to aryl/heteroaryl chlorides via a palladium-mediated Suzuki coupling reaction to yield the corresponding derivatives in moderate to good yields.