154476-88-7Relevant academic research and scientific papers
Vinylogous Blaise Reaction: Conceptually New Synthesis of Pyridin-2-ones
Rao, H. Surya Prakash,Muthanna, Nandurka,Padder, Ashiq Hussain
supporting information, p. 1649 - 1653 (2018/06/26)
A conceptually new synthesis of pyridine rings by a [C 4 + CN] assembly has been developed by applying a vinylogous version of the classic Blaise reaction. The zinc-mediated reaction of (het)aryl or alkyl nitriles with ethyl-4-bromocrotonate pr
Synthesis of mono- and diaza-'pyridones' via stille coupling of alkoxystannanes
Smith, Charlotte L.,Hirschh?user, Christoph,Malcolm, Georgia K.,Nasrallah, Daniel J.,Gallagher, Timothy
, p. 1904 - 1908 (2014/08/18)
Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted 'pyridone' moieties via Stille cross-coupling. Both pyridyl and a series of diazinyl stannanes are prepared, and options for unmasking (via demethylation or debenzylation) of the pyridone unit are evaluated. Georg Thieme Verlag Stuttgart. New York.
An active, general, and long-lived palladium catalyst for cross-couplings of deactivated (hetero)aryl chlorides and bromides with arylboronic acids
Hoshi, Takashi,Honma, Tomonobu,Mori, Ayako,Konishi, Maki,Sato, Tsutomu,Hagiwara, Hisahiro,Suzuki, Toshio
, p. 11513 - 11524 (2013/12/04)
An active, general, and long-lived palladium catalyst for Suzuki-Miyaura reactions of aryl and heteroaryl chlorides deactivated by steric hindrance, electron richness, and coordinating functional groups is reported. In reactions of arylbromide bearing two o-tert-butyl substituents, C(sp3)-H arylation of the tert-butyl group, rather than the Suzuki-Miyaura reaction, proceeded in excellent yield. The key to the success of the reactions was the development of biphenylene-substituted dicyclohexylruthenocenylphosphine (CyR-Phos) as a supporting ligand.
