154477-55-1

Basic information

• Product Name: Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl
• Synonyms: Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl;2-[4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]phenyl]-2,2-dimethylacetic acid methyl ester;METHYL-4-4(4-HYDROXY DIPHENYL-METHYL)-PIPERIDINE-1-OXOBUTYL-2-2-DIMETHYL PHENYL ACETIC ACID;Methyl 2-(4-(4-(4-(hydroxydiphenylMethyl)piperidin-1-yl)butanoyl)phenyl)-2-Methylpropanoate;Methyl 2-(4-(4-((4-((4-hydroxyphenyl)(phenyl)methyl)-piperidin-1-yl)oxy)butyl)phenyl)-2-methylpro;1-Oxo Fexofenadine Methyl Ester;Methyl 4- 4- 4-(hydroxydiphenylMethyl)-1-piperidinyl -1-butyryl -alpha, alpha-diMethylbenzene acetate;Methyl 2-(4-(4-((4-((4-hydroxyphenyl)(phenyl)Methyl)piperidin-1-yl)oxy)butyl)phenyl)-2-Methylpropanoate
• CAS NO: 154477-55-1
• Molecular Formula: C₃₃H₃₉NO₄
• Molecular Weight: 513.674
• EINECS: 1312995-182-4
• Mol File: 154477-55-1.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 657.185 °C at 760 mmHg
• Flash Point: 351.253 °C
• Appearance: /
• Density: 1.131
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 2-8°C
• PKA: 13.32±0.29(Predicted)
• CAS DataBase Reference: Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl(154477-55-1)
• EPA Substance Registry System: Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl(154477-55-1)

Safety Data

• Hazardous Substances Data: 154477-55-1(Hazardous Substances Data)

Usage

Description

Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl is a complex chemical compound characterized by its piperidine-based structure with a butyl group and a dimethylphenyl group. The molecule is further distinguished by the presence of hydroxy and diphenylmethyl groups, which contribute to its potential medicinal or functional properties. Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl may be utilized in pharmaceutical research or various industrial applications, although further analysis and study are required to ascertain its specific uses and effects.

Uses

Used in Pharmaceutical Research:
Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl is used as a research compound for exploring its potential medicinal properties. Its unique structure, including the piperidine, butyl, and dimethylphenyl groups, as well as the hydroxy and diphenylmethyl moieties, may offer valuable insights into the development of new drugs or therapeutic agents.
Used in Industrial Applications:
In the industrial sector, Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl may be employed as a functional chemical for specific purposes. Its complex structure and the presence of various functional groups could provide it with unique properties that are beneficial in certain applications, such as in the synthesis of other compounds or as an intermediate in chemical processes.

InChI:InChI=1/C33H39NO4/c1-32(2,31(36)38-3)26-18-16-25(17-19-26)30(35)15-10-22-34-23-20-29(21-24-34)33(37,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29,37H,10,15,20-24H2,1-3H3

Upstream product

• 958378-24-0 4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]-2-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]butyric acid ethyl ester 
• 115-46-8 C₁₈H₂₁NO 
• 154477-54-0 2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid, methyl ester 
• 154825-96-4 fexofenadine methyl ester 
• 547-63-7 Methyl isobutyrate 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 4559-96-0 1-(4-bromophenyl)-4-chlorobutan-1-one 
• 108-86-1 bromobenzene 
• 140-29-4 phenylacetonitrile 
• 169280-21-1 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionic acid 
• 169280-15-3 2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid , N-methoxy-N-methylamide 
• 169280-16-4 2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 36293-05-7 2-methyl-2-phenylpropanoyl chloride 

Downstream Products

• 154825-96-4 fexofenadine methyl ester 
• 83799-24-0 fexofenadine 
• 76811-98-8 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid 

Relevant articles and documents

Preparation method of fexofenadine

The invention provides a preparation method of fexofenadine, which comprises the following steps: by using bromobenzene as a raw material, carrying out Friedel-Crafts acylation reaction to obtain 4'-bromo-4-chlorophenone ; enabling 4'-bromo-4-chlorobutanone and 1-methoxy-1-(trimethylsiloxy)-2-methyl-1-propene to subjected to coupling reaction to obtain 2-[4-(4 -chloro-1-butyryl)phenyl]-2-methyl methyl propionate; and sequentially carrying out N-alkylation, carbonyl reduction and alkaline hydrolysis on 2-[4-(4 -chloro-1-butyryl)phenyl]-2-methylpropanoate to obtain fexofenadine. The method has the advantages of cheap and easily available raw materials, easiness in operation, high yield, low cost, no meta-isomer, suitability for industrial production and the like.

METHODS AND COMPOSITIONS FOR TREATING INFECTION

Provided herein are compositions and methods for treating or preventing infection.

INTERMEDIATES USEFUL FOR THE SYNTHESIS OF FEXOFENADINE, PROCESSES FOR THEIR PREPARATION AND FOR THE PREPARATION OF FEXOFENADINE

Intermediates useful for the synthesis of fexofenadine, processes for their preparation and processes for the synthesis of fexofenadine are described.