169280-16-4

Basic information

• Product Name: 2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide
• Synonyms: 2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide
• CAS NO: 169280-16-4
• Molecular Weight: 207.272
• Mol File: 169280-16-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide(169280-16-4)
• EPA Substance Registry System: 2-methyl-2-phenyl-propionic acid , N-methoxy-N-methylamide(169280-16-4)

Safety Data

• Hazardous Substances Data: 169280-16-4(Hazardous Substances Data)

Upstream product

• 36293-05-7 2-methyl-2-phenylpropanoyl chloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 28509-24-2 tert-butylmethyl ether 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 140-29-4 phenylacetonitrile 
• 57625-74-8 methyl 2-methyl-2-phenylpropionate 

Downstream Products

• 202189-78-4 Bilastine 
• 154477-54-0 2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid, methyl ester 
• 154477-55-1 methyl 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoate 
• 770-85-4 2-methyl-2-phenylbutan-3-one 
• 169280-21-1 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionic acid 

Relevant articles and documents

A new and competitive synthetic approach for an antihistamine agent, bilastine

Efforts towards the novel synthesis of second generation non-sedating antihistamine drug, Bilastine was described in this manuscript. This competitive synthetic approach involves the convergent synthesis of Bilastine via simple Friedel-Crafts acylation as an alternate for earlier reported Stille and Suzuki couplings. The selectivity in Friedel-Crafts acylation reaction with chloro acetyl chloride on different substituted arenes was studied and employed the best conditions for the synthesis of Bilastine. Further synthetic approach involves the deoxygenation of aryl ketone to corresponding alkane in single step and finally provides Bilastine with 39% of improved overall yields, utilizing simple and cost-effective reagents, suitable for kilogram scale synthesis.

SOLID STATE FORMS OF 2-[4-(2-{4-[1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL]-1-PIPERIDINYL}ETHYL)PHENYL]-2-METHYLPROPANOIC ACID AND PROCESS FOR PREPARATION THEREOF

The present invention relates to solid state forms of 2-[4-(2-{4-[1 -(2-ethoxyethyl)- 1H-benzimidazol-2-yl] - 1 -piperidinyl } ethyl)phenyl]-2-methylpropanoic acid compound represented by the following structural formula- 1 and process for preparation the

NOVEL PROCESS FOR THE PREPARATION OF 2-[4-(2-{4-[1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL]-1-PIPERIDINYL}ETHYL) PHENYL]-2-METHYLPROPANOIC ACID

The present invention relates to novel process for the preparation of 2-[4-(2-{4-[l-(2- ethoxyethyl)-lH-benzimidazol-2-yl]-l-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid represented by the following structural formula- 1. Formula- 1 The present invention also provides novel intermediate compounds useful for the preparation of compound of formula- 1.