154492-12-3

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 53123-88-9 sirolimus 
• 331810-10-7 31-(trimethylsilylether)rapamycin 
• 1192721-95-1 28-oxy trimethylsilyl-43-0-(4-nitrophenoxycarbonyl)oxy rapamycin 

Downstream Products

• 156598-70-8 [(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12SR,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32SR,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl] N-(2-pyridylmethyl)carbamate 
• 156598-66-2 Rapamycin 42-ester with 2-(pyridin-2-yl)-ethyl carbamic acid 
• 173554-21-7 [(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl] N-(2-morpholinoethyl)carbamate 

Relevant academic research and scientific papers

MTORC MODULATORS AND USES THEREOF

Novel rapamycin analogs and uses thereof are disclosed herein. The rapamycin analogs of the present disclosure show increased mTORC1 specificity and lowered mTORC2 specificity relative to rapamycin.

Rapamycin of the nitrogen heterocyclic derivatives and use (by machine translation)

The present invention relates to nitrogen heterocyclic derivatives of rapamycin, and use thereof. Specifically, the invention relates to compounds represented by general formula I compound: or its pharmaceutically acceptable salts, solvates, isomers, este

Phosphorus-containing macrocycles

This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties.

Carbamates of rapamycin

The invention concerns a compound of the structure wherein R1 and R2 are each, independently, hydrogen, -CONH-[(CR3R4)m(-A-(CR5R6)n)p]q-B; R