154499-87-3

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 154499-80-6 4,6-dimethylpyrimidin-2-yl trifluoromethanesulfonate 
• 123-54-6 acetylacetone 
• 93296-09-4 4-methoxyphenylzinc chloride 
• 22325-27-5 4,6-dimethyl-2-meraptopyrimidine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 16879-40-6 2-iodo-4,6-dimethylpyrimidine 
• 321680-94-8 2-(4-methoxybenzylthio)-4,6-dimethylpyrimidine 
• 108-79-2 4,6-dimethyl-2(1H)-pyrimidinone 
• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 1379459-01-4 2-(p-methoxyphenyl)-pyrimidine-4,6-dicarbaldehyde 
• 1379458-96-4 2-(p-methoxyphenyl)-pyrimidine-4,6-dicarbaldehydebis(2-pyridyl hydrazone) 
• 81015-35-2 4-(4,6-dimethyl-pyrimidin-2-yl)-phenol 

Relevant academic research and scientific papers

Transition-Metal-Free Cross-Coupling of Aryl and Heteroaryl Thiols with Arylzinc Reagents

Cross-coupling of (hetero)arylthiols with arylzinc reagents via C-S cleavage was performed under transition-metal-free conditions. The reaction displays a wide scope of substrates and high functional-group tolerance. Electron-rich and -deficient (hetero)arylthiols and arylzinc reagents can be employed in this transformation. Mg2+ and Li+ ions were demonstrated to facilitate the reaction.

An expeditious route toward pyrazine-containing nucleoside analogues

An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.

Molecular motion in zinc hydrazone grid complexes

Four new grid forming hydrazone ligands substituted with methoxy and dimethylamino groups were synthesised. Combination of these ligands with zinc triflate in acetonitrile resulted in self-assembly to form grids as indicated by 1H NMR and ES-MS

A convenient method for the preparation of highly substituted 1101 pyrimidines: Synthesis of tri- and tetra-subsituted pyrimidines from 1,3-dicarbonyl compounds and N,N,N′-tris-(trimethylsilyl)amidines

A modification of the Pinner pyrimidine synthesis has been developed that utilizes trimethylsilyl amidines and results in greatly improved yield of highly substituted pyrimidines.

SYNTHESIS OF PYRIMIDINYL TRIFLATES AND PALLADIUM-CATALYZED COUPLING WITH ORGANOTIN AND ORGANOZINC REAGENTS

Pyrimidinyl triflates have been synthesized from pyrimidinones using triflic anhydride in the presence of triethylamine.The triflates, in the pyrimidine electrophilic positions, are versatile intermediates for substitution reactions.Carbon substituents ar