154504-43-5

Basic information

• Product Name: [1,3]DIOXOLO[4,5-G]QUINOLIN-8(5H)-ONE
• Synonyms: [1,3]DIOXOLO[4,5-G]QUINOLIN-8(5H)-ONE
• CAS NO: 154504-43-5
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.16748
• Mol File: 154504-43-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 285-289 °C
• Boiling Point: 350.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.419±0.06 g/cm3(Predicted)
• PKA: -1.05±0.20(Predicted)
• CAS DataBase Reference: [1,3]DIOXOLO[4,5-G]QUINOLIN-8(5H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: [1,3]DIOXOLO[4,5-G]QUINOLIN-8(5H)-ONE(154504-43-5)
• EPA Substance Registry System: [1,3]DIOXOLO[4,5-G]QUINOLIN-8(5H)-ONE(154504-43-5)

Safety Data

• Hazardous Substances Data: 154504-43-5(Hazardous Substances Data)

Usage

General Description

[1,3]DIOXOLO[4,5-G]QUINOLIN-8(5H)-ONE, also known as Dioxoloquinolinone, is a chemical compound with a unique structure and pharmacological properties. It is part of the quinolone class of compounds and has been studied for its potential anti-cancer and anti-inflammatory activities. Dioxoloquinolinone has also shown promise in inhibiting the growth of tumor cells and inducing cell cycle arrest and apoptosis. Additionally, it has been investigated for its potential in treating neurodegenerative diseases such as Parkinson's and Alzheimer's. Its unique structure and diverse pharmacological activities make it an interesting compound for further research and potential therapeutic applications.

Upstream product

• 28657-75-2 2-amino-4,5-methylenedioxy-acetophenone 
• 109-94-4 formic acid ethyl ester 
• 2033-24-1 cycl-isopropylidene malonate 
• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 
• 149-73-5 trimethyl orthoformate 
• 14205-65-3 ethyl 8-hydroxy-1,3-dioxolo[4,5-g]quinoline-7-carboxylate 
• 26893-27-6 8-hydroxy-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid 
• 369398-78-7 5-((benzo[d][1,3]dioxol-5-ylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 56136-84-6 methyl 3,4-(methylenedioxy)-6-nitrophenyl ketone 

Downstream Products

• 500214-46-0 N-(6,7-methylenedioxyquinolin-4-yl)-N-(2-N,N-dimethylaminoethyl)-2-iodo-4,5-dimethoxybenzamide 
• 847573-85-7 N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(4-benzylpiperazin-1-yl)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 758717-90-7 N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-dibenzylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 847573-93-7 8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one 
• 758717-91-8 12-(2-dibenzylamino-ethyl)-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one 
• 847573-81-3 N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-tert-butylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 847573-89-1 12-[2-(benzyl-tert-butyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one 
• 847573-83-5 N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(piperidin-1-yl)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 847573-80-2 N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 847573-79-9 N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-ethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 847573-84-6 N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(4-methylpiperidin-1-yl)ethyl]-2-iodo-4,5-dimethoxybenzamide 
• 847573-88-0 12-[2-(benzyl-isopropyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one 
• 847573-87-9 12-[2-(benzyl-ethyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one 
• 847573-78-8 N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-methylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide 

Relevant articles and documents

Cu(I)-Catalyzed Alkynylation of Quinolones

Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transformation has also been explored, and the methodology has been applied in the synthesis of the enantioenriched tetrahydroquinoline alkaloid cuspareine.

METHODS FOR TREATING GASTRIC AND PANCREATIC MALIGNANCIES

The invention provides methods and pharmaceutical compositions for treating pancreatic cancer or gastric cancer or a metastasis thereof.

Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates

We have synthesized quinolinones with potential antiparasitic and anti-HIV activities by an original two-step method involving microwave irradiation and have evaluated their activities against Plasmodium falciparum, Leishmania donovani, Trichomonas vaginalis, and HIV. None of the tested compounds had been previously described using this method of synthesis. One of the compounds had interesting antiparasitic and anti-HIV activity, which could be improved by substitution with different radicals.