15451-33-9Relevant academic research and scientific papers
A new ruthenium-catalyzed cleavage of a carbon-carbon triple bond: Efficient transformation of ethynyl alcohol into alkene and carbon monoxide
Datta, Swarup,Chang, Chia-Lung,Yeh, Kuo-Liang,Liu, Rai-Shung
, p. 9294 - 9295 (2003)
We report a new and efficient ruthenium-catalyzed reaction that transforms ethynyl alcohol into alkene and carbon monoxide. The most efficient catalysts are TpRu(PPh3)(CH3CN)2PF6 (10 mol %) and lithium triflate
Evidence for the transition from SN to ET mechanism in the reaction of arene radical anion with alkyl halide evoked by the introduction of an electron withdrawing substituent into radical anion
Panteleeva, Elena V.,Vaganova, Tamara A.,Shteingarts, Vitalij D.,Bilkis, Isaak I.
, p. 8465 - 8466 (1995)
The interaction of potassium salts of benzonitrile and 1,4-dicyanobenzene radical anions with cyclopropylmethyl bromide provides benzylcyclopropane, in the first case, and 4-alkyl- benzonitriles together with 2-alkyl-1,4-dicyanobenzenes containing both cyclopropylmethyl and it's isomeric 3-butenyl fragment, in the second case. These results provide evidence for the change of reaction mechanism from SN to ET.
A Ball-Milling-Enabled Cross-Electrophile Coupling
Jones, Andrew C.,Nicholson, William I.,Leitch, Jamie A.,Browne, Duncan L.
supporting information, p. 6337 - 6341 (2021/08/23)
The nickel-catalyzed cross-electrophile coupling of aryl halides and alkyl halides enabled by ball-milling is herein described. Under a mechanochemical manifold, the reductive C-C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive setups, in reaction times of 2 h. The mechanical action provided by ball milling permits the use of a range of zinc sources to turnover the nickel catalytic cycle, enabling the synthesis of 28 cross-electrophile coupled products.
Efficient preparation method of 1-aryl-4-butene compound
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Paragraph 0063-0066; 0071-0074, (2020/05/30)
The invention belongs to the technical field of fine chemicals and related chemistry, and provides an efficient preparation method of a 1-aryl-4-butene compound. The 1-aryl-4-butene compound can be obtained by taking halogen-containing methyl aromatic hyd
Umpolung of Carbonyl Groups as Alkyl Organometallic Reagent Surrogates for Palladium-Catalyzed Allylic Alkylation
Zhu, Dianhu,Lv, Leiyang,Li, Chen-Chen,Ung, Sosthene,Gao, Jian,Li, Chao-Jun
supporting information, p. 16520 - 16524 (2018/11/23)
Palladium-catalyzed allylic alkylation of nonstabilized carbon nucleophiles is difficult and remains a major challenge. Reported here is a highly chemo- and regioselective direct palladium-catalyzed C-allylation of hydrazones, generated from carbonyls, as a source of umpolung unstabilized alkyl carbanions and surrogates of alkyl organometallic reagents. Contrary to classical allylation techniques, this umpolung reaction utilizes hydrazones prepared not only from aryl aldehydes but also from alkyl aldehydes and ketones as renewable feedstocks. This strategy complements the palladium-catalyzed coupling of unstabilized nucleophiles with allylic electrophiles by providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organometallic reagents.
Amine-Activated Iron Catalysis: Air- and Moisture-Stable Alkene and Alkyne Hydrofunctionalization
Challinor, Amy J.,Calin, Marc,Nichol, Gary S.,Carter, Neil B.,Thomas, Stephen P.
supporting information, p. 2404 - 2409 (2016/08/16)
A simple alkylamine [(iPr)2NEt] has been used to activate an air- and moisture-stable iron(II) pre-catalyst for alkene and alkyne hydrofunctionalization reactions. This amine activation has enabled the highly operationally simple hydrosilylatio
Short access to 4-alkenylbenzonitriles: Reaction of anionic reduced forms of terephthalonitrile with alkenyl bromides
Panteleeva, Elena V.,Haufe, Günter,Shteingarts, Vitalij D.
, p. 1616 - 1618 (2008/02/05)
Direct one-pot syntheses of 4-(ω-alkenyl)-benzonitriles in high yields have been achieved via the reaction of terephthalonitrile dianion with allyl or co-alkenyl bromides in liquid ammonia. Georg Thieme Verlag Stuttgart.
Highly efficient, general procedure for the preparation of alkylzinc reagents from unactivated alkyl bromides and chlorides
Huo, Shouquan
, p. 423 - 425 (2007/10/03)
(Matrix presented) Alkylzinc bromides have been efficiently prepared by the direct insertion of zinc metal (dust, powder, granule, shot), activated with 1-5 mol % I2, into alkyl bromides in a polar aprotic solvent. The zinc reagents thus formed undergo Ni- and Pd-catalyzed cross-coupling with aryl halides to produce functionalized alkylarenes in excellent yields.
Oxabispidine compounds useful in the treatment of cardiac arrhyythmias
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, (2008/06/13)
There is provided compounds of formula I, wherein R1, R2, R3, R4, R41to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
Bispidine antiarrhythmic compounds
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, (2008/06/13)
There is provided a compound of formula I, wherein R1, R2, R9, R10, R11, R12, X, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
