15456-86-7

Usage

Uses

Used in Pharmaceutical Industry:
Pyridazine, 3,6-dione, 4-bromo-1,2-dihydrois used as an intermediate in the synthesis of pharmaceutical drugs for its potential medicinal properties. Its unique structure allows for the development of new drug candidates with specific therapeutic effects.
Used in Organic Synthesis:
In the field of organic synthesis, Pyridazine, 3,6-dione, 4-bromo-1,2-dihydrois employed as a building block to create more complex compounds. Its heterocyclic nature and functional groups enable the formation of various derivatives with diverse applications in chemical research and development.
Used in Research:
Pyridazine, 3,6-dione, 4-bromo-1,2-dihydrois utilized in research settings to explore its chemical properties, reactivity, and potential applications in the development of new materials and compounds. Its unique structure and functional groups make it an interesting subject for scientific investigation and experimentation.

InChI:InChI=1/C4H3BrN2O2/c5-2-1-3(8)6-7-4(2)9/h1H,(H,6,8)(H,7,9)

Upstream product

• 5926-51-2 bromomaleic anhydride 
• 10034-93-2 hydrazinium sulfate 

Downstream Products

• 6082-66-2 3,4,6-trichloropyridazine 
• 910229-65-1 5-bromo-6-oxo-1,6-dihydropyridazin-3-yl 2,4,6-triisopropylbenzenesulfonate 
• 10344-42-0 4-bromo-3,6-dichloro-pyridazine 
• 1003944-29-3 C₄HBrCl₂N₂ 
• 202931-70-2 3,6-dichloro-4-(pyridin-4-yl)pyridazine 
• 943025-98-7 4-bromo-2-{[4-(methyloxy)phenyl]methyl}-6-({[4-(methyloxy)phenyl]methyl}oxy)-3(2H)-pyridazinone 
• 943025-99-8 5-bromo-2-{[4-(methyloxy)phenyl]methyl}-6-({[4-(methyloxy)phenyl]methyl}oxy)-3(2H)-pyridazinone 

Relevant academic research and scientific papers

Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones

The present invention relates to methods for treating Neisseria Gonorrhoeae infection which comprises administering to a subject in need thereof novel 1,2-dihydro-2a,5,8a-triazaacenaphthylene-3,8-dione compounds: or pharmaceutically acceptable salts thereof and/or corresponding pharmaceutical compositions.

THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF

Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with thyroid hormone receptor activity. The methods and compositions disclosed herein include the use of at least one thyroid hormone receptor agonist.

A general approach to access 5,6-dihydroindolo-naphthyridine ring system

We report a general approach for the synthesis of 5,6-dihydroindolo-naphthyridine ring system via an intramolecular cyclization of the indole NH to an alkene moiety as the key step.

Synthesis of new derivatives of 10H-benzo[b]pyridazino[3,4-e][1,4]thiazines

New 10H-benzo[b]pyridazino[3,4-e][1,4]thiazines were prepared and evaluated for inhibitory activity against soybean 15-lipoxygenase enzyme. These compounds were synthesized by the sequential treatment of 4-bromo-3,6-dichloropyridazine with 2-aminothiophenol and a secondary amine with the subsequent heterocyclization in the presence of sodium amide.

Access to 4-alkylaminopyridazine derivatives via nitrogen-assisted regioselective pd-catalyzed reactions

3-Substituted, 6-substituted, and unsymmetrical 3,6-disubstituted 4-alkylaminopyridazines were prepared from a sequence of three chemo- and regioselective reactions combining amination and palladium-catalyzed cross-coupling reactions, such as reductive dehalogenation and Suzuki-Miyaura reactions. Extension of the methodology to Sonogashira reaction yielded a novel class of 3-substituted pyrrolopyridazines.

MAP KINASE MODULATORS AND USES THEREOF

The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38a MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising adm

TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C

The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis

Tricyclic nitrogen-containing compounds of Formula (I) and pharmaceutically acceptable derivatives thereof: compositions containing them, their use in the treatment of tuberculosis, and methods for the preparation of such compounds.