154732-05-5Relevant articles and documents
Synthesis of the tetracyclic core of daphnilactone B-type and yuzurimine-type alkaloids
Belanger, Guillaume,Boudreault, Jonathan,Levesque, Francois
, p. 6204 - 6207 (2011)
The core of daphnilactone B-type and yuzurimine-type alkaloids was synthesized in only 16 steps from a known β-allyl-γ-butyrolactone. The key sequence of Vilsmeier-Haack cyclization and intramolecular azomethine ylide cycloaddition allowed the constructio
Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors
Powell, Noel A.,Ciske, Fred L.,Cai, Cuiman,Holsworth, Daniel D.,Mennen, Ken,Van Huis, Chad A.,Jalaie, Mehran,Day, Jacqueline,Mastronardi, Michelle,McConnell, Pat,Mochalkin, Igor,Zhang, Erli,Ryan, Michael J.,Bryant, John,Collard, Wendy,Ferreira, Suzie,Gu, Chungang,Collins, Roxane,Edmunds, Jeremy J.
, p. 5912 - 5949 (2008/03/18)
We report the design and synthesis of a series of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as orally bioavailable small molecule inhibitors of renin. Compounds with a 2-methyl-2-aryl substitution pattern exhibit potent renin inhibition and good pe
