15482-19-6

Basic information

• Product Name: 1-Propanone, 2-hydroxy-2-methyl-1-(2-methylphenyl)-
• CAS NO: 15482-19-6
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol File: 15482-19-6.mol

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-hydroxy-2-methyl-1-(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-hydroxy-2-methyl-1-(2-methylphenyl)-(15482-19-6)
• EPA Substance Registry System: 1-Propanone, 2-hydroxy-2-methyl-1-(2-methylphenyl)-(15482-19-6)

Safety Data

• Hazardous Substances Data: 15482-19-6(Hazardous Substances Data)

Upstream product

• 82128-96-9 2-trimethylsilyloxy-2-(2-methylphenyl)acetonitrile 
• 67-64-1 acetone 
• 529-20-4 2-methylphenyl aldehyde 

Relevant articles and documents

Photochemical preparation of highly functionalized 1-indanones

A series of o-alkylphenyl alkyl ketones 1 were synthesized by different methods. The presence of a leaving group X adjacent to the carbonyl group is the special peculiarity of these ketones. Upon irradiation the keto carbonyl group of these compounds undergoes an n-π* excitation followed by a 1,5-hydrogen migration from the o-alkyl substituent to the carbonyl oxygen atom. The thus formed 1,4-diradicals are subject to a very rapid elimination of acid HX, giving 1,5-diradicals. We called this process spin center shift. After intersystem crossing these diradicals cyclize to 1-indanones 20 in good yields. Depending on the solvent and on substituents, o-alkoxyalkyl ketones 22 or benzo-[c]furanes 21 are obtained as byproducts. The mechanism of the cyclization was elucidated by quantum chemical calculations and kinetic measurements.